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Post-translational modifications of proteins: some problems left to solve.

作者信息

Yan S C, Grinnell B W, Wold F

出版信息

Trends Biochem Sci. 1989 Jul;14(7):264-8. doi: 10.1016/0968-0004(89)90060-1.

DOI:10.1016/0968-0004(89)90060-1
PMID:2672445
Abstract

Three major questions regarding the post-translational modification of amino acid side chains in proteins are briefly considered: (1) What are the biological functions of the reactions, (2) what is the specificity of the processing reactions in selecting only a few or sometimes even only one residue for modification, and (3) how do we solve the uniqueness of the processing steps in the production of recombinant proteins? The answers to these questions are not obvious at this time.

摘要

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