Boobis A R, Fawthrop D J, Davies D S
Trends Pharmacol Sci. 1989 Jul;10(7):275-80. doi: 10.1016/0165-6147(89)90027-8.
There is increasing evidence that the mechanisms of chemically mediated cell death are common to a wide variety of cell types and to a large number of toxic compounds. The perturbation of Ca2+ homeostasis appears to be particularly important and may be due to modification of SH-groups in key enzymes. Donald Davies and colleagues discuss the mechanisms by which early events induced by exposure to toxic chemicals may lead to these changes, and their possible consequences. It is now clear that reduced glutathione plays a pivotal role, not only in detoxifying reactive compounds but also in reversing the early biochemical changes in the cell.
越来越多的证据表明，化学介导的细胞死亡机制在多种细胞类型和大量有毒化合物中是常见的。Ca2+ 稳态的扰动似乎尤为重要，这可能是由于关键酶中 SH 基团的修饰所致。唐纳德·戴维斯及其同事讨论了接触有毒化学物质所引发的早期事件可能导致这些变化的机制及其可能的后果。现在很清楚，还原型谷胱甘肽不仅在解毒活性化合物方面发挥关键作用，而且在逆转细胞早期生化变化方面也发挥关键作用。
