Čanković Miloš, Bokor-Bratić Marija, Novović Zdenka
Miloš Čanković DDM, MSc, PhD, Dental Clinic Oral Medicine Section, Faculty of Medicine, Hajduk Veljkova 12, Novi Sad, Serbia;
Acta Dermatovenerol Croat. 2015;23(4):270-6.
The onset and aggravation of symptoms in patients with oral lichen planus (OLP) are related to psychosomatic constitution and stress involvement. The aim of this study was to evaluate the influence of stressful life events and neuroticism as a personality trait in patients with OLP. A total of 32 patients with clinically and histopathological proven cases of OLP (16 with the nonerosive and 16 with erosive form), along with 31 healthy controls without oral lesions matched for age and sex were included in the study. Neurotic tendency and intensity of anxiety, depression, and negative affects and the number and type of stressful life events were investigated by the instruments Big Five Plus Two and Holmes and Rahe`s Social Readjustment Rating Scale, respectively. Data about life experience in war and its consequences were also collected. Univariate and multivariate analysis showed significantly greater anxiety, depression and negative affects tendency, as well as greater intensity and number of experienced stressful life events compared with controls (P<0.01). The distribution of subjects with at least one stressful event (P<0.01), family matters (P<0.01) and war experiences (P<0.05) was significant in the OLP group. The logistic regression results (OR=1.97) indicate that with each new stressful event a person is about two times more likely to get OLP. The degree, number, and type of stressful life changes and neuroticisms tendency independently play an important role in the onset or reactivation of OLP, depending on the individual's psychological constitution and the large differences in each person's ability to cope and their particular reactions to stress.
口腔扁平苔藓（OLP）患者症状的发作和加重与身心体质及压力因素有关。本研究旨在评估应激性生活事件和作为人格特质的神经质对OLP患者的影响。本研究共纳入32例经临床和组织病理学确诊的OLP患者（16例非糜烂型和16例糜烂型），以及31名年龄和性别匹配的无口腔病变的健康对照者。分别采用大五人格量表和霍尔姆斯与拉赫社会再适应评定量表调查神经质倾向以及焦虑、抑郁和消极情绪的强度，以及应激性生活事件的数量和类型。还收集了有关战争中的生活经历及其后果的数据。单因素和多因素分析显示，与对照组相比，患者的焦虑、抑郁和消极情绪倾向明显更强，经历的应激性生活事件的强度和数量也更多（P<0.01）。在OLP组中，至少经历一次应激事件（P<0.01）、家庭事务（P<0.01）和战争经历（P<0.05）的受试者分布具有显著性。逻辑回归结果（OR=1.97）表明，每出现一次新的应激事件，一个人患OLP的可能性就会增加约两倍。应激性生活变化的程度、数量和类型以及神经质倾向独立地在OLP的发病或复发中起重要作用，这取决于个体的心理体质以及每个人应对能力的巨大差异和他们对压力的特定反应。
