Andreasen E E, Andersen H J, Jensen H K
Ugeskr Laeger. 1989 Aug 7;151(32):2021-6.
A review is presented of progestogens which assume a central position in future replacement therapy. The types and dosages of progestogens are of considerable significance for the effects and side effects. Attention is, therefore drawn to the plasma concentration and the minimal effective doses in the following two clinical treatments. Oestrogen primed endometrium is correctly transformed after treatment for 12 days with the following daily dosages: Dydrogesterone = 20 mg, medroxyprogesterone = 10 mg, norethisterone/norethisterone acetate = 0.7 mg, desogestrel = 150 micrograms or levonorgestrel approximately 100 micrograms. Inhibition of ovulation and contraception are obtained by means of the following daily doses: Medroxyprogesterone = 10 mg, norethisterone/norethisterone acetate = 350 micrograms, levonorgestrel = 50 micrograms, desogestrel = 60 micrograms, gestodene = 40 micrograms or norgestimate 250 micrograms.
本文综述了在未来替代疗法中占据核心地位的孕激素。孕激素的类型和剂量对其疗效和副作用具有重要意义。因此，在以下两种临床治疗中需关注血浆浓度和最小有效剂量。用以下每日剂量治疗12天后，雌激素预处理的子宫内膜能正确转化：地屈孕酮=20毫克，甲羟孕酮=10毫克，炔诺酮/醋酸炔诺酮=0.7毫克，去氧孕烯=150微克或左炔诺孕酮约100微克。通过以下每日剂量可抑制排卵和避孕：甲羟孕酮=10毫克，炔诺酮/醋酸炔诺酮=350微克，左炔诺孕酮=50微克，去氧孕烯=60微克，孕二烯酮=40微克或诺孕酯250微克。
