Liu Yaping, Ma Huilong, Zhang Liangwei, Cui Yajing, Liu Xiaoting, Fang Jianguo
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Chem Commun (Camb). 2016 Feb 7;52(11):2296-9. doi: 10.1039/c5cc09998f.
The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.
首个用于对活细胞中线粒体硫氧还蛋白还原酶（TrxR2）进行成像的开-关型探针Mito-TRFS被报道。在帕金森病（PD）的细胞模型中，Mito-TRFS染色显示TrxR2活性急剧下降，为TrxR2功能障碍与PD病因之间提供了一种机制联系。
