Machado F S, Telles E C, Pinho B, Soares R, Rego F, Nazaré J, Amram S S
Acta Med Port. 1989 Jan-Feb;2(1):47-54.
The authors emphasize some adrenal embryologic features, mainly the cortex and medulla relationships. After brief considerations both on the biosynthesis and physiologic actions of aldosterone, the Primary Hyperaldosteronism physiopathology is described. The clinical, biochemical and anatomic evidences are presented as a basis for both the Syndrome diagnosis and its subtypes. The theoretical and practical aspects of the diagnostic tests are also referred as a basis for the rationale of the medical and surgical therapeutic approach. Some clinical and biochemical similar aspects between the Syndrome of Hyperaldosteronism and Essential Hypertension with low renin, are put forward as a possible physiopathologic link that could eventually contribute for a better understanding of the pathogenesis of Essential Hypertension.
作者强调了一些肾上腺胚胎学特征,主要是皮质与髓质的关系。在简要讨论醛固酮的生物合成和生理作用后,描述了原发性醛固酮增多症的病理生理学。介绍了临床、生化和解剖学证据,作为该综合征及其亚型诊断的基础。诊断试验的理论和实践方面也被提及,作为药物和手术治疗方法原理的基础。提出了醛固酮增多症综合征与低肾素原发性高血压之间一些临床和生化方面的相似之处,作为一种可能的病理生理联系,最终可能有助于更好地理解原发性高血压的发病机制。