Kawamoto Ryuichi, Katoh Takeaki, Ninomiya Daisuke, Kumagi Teru, Abe Masanori, Kohara Katsuhiko
a Department of Community Medicine.
b Department of Geriatric Medicine , Ehime University Graduate School of Medicine , Ehime , Japan.
Endocr Res. 2016 May;41(2):116-23. doi: 10.3109/07435800.2015.1094085. Epub 2016 Jan 4.
Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated.
The present study included 100 postmenopausal women (mean ± standard deviation, 68 ± 7 years) from a rural village in Japan. The Nordic walking program of 120 min per week was performed for 12 weeks. Before and after the intervention, SUA, TG, various relevant factors and homeostasis model assessment of insulin resistance (HOMA-IR) were measured.
Multivariate linear regression analysis showed that baseline TG and γ-glutamyltransferase (GGT) were significantly associated with baseline HOMA-IR. After the 12-week training program, changes in TG, SUA and GGT were significantly associated with changes in HOMA-IR. In addition to their direct associations, we observed a synergistic association between changes in TG and SUA and changes in HOMA-IR. Participants were divided into three groups (tertiles) according to changes in TG and SUA. The tertiles of changes in SUA correlated significantly with changes in HOMA-IR in participants in the tertile with the greatest decrease in TG (r = 0.525, p = 0.001), but not in the other two tertiles of change in TG (r = 0.049, p = 0.699). There was a significant interaction between SUA and TG for changes in HOMA-IR (β = 0.281, p = 0.005). These results suggest that changes in TG and SUA are synergistic factors associated with changes in insulin resistance after a 12-week walking exercise program in community-dwelling older women.
血清尿酸（SUA）和甘油三酯（TG）水平与胰岛素抵抗密切相关；然而，社区老年女性进行步行锻炼计划后的相关性尚未得到研究。
本研究纳入了日本一个乡村的100名绝经后女性（平均±标准差，68±7岁）。每周进行120分钟的北欧式健走计划，持续12周。在干预前后，测量SUA、TG、各种相关因素以及胰岛素抵抗的稳态模型评估（HOMA-IR）。
多变量线性回归分析显示，基线TG和γ-谷氨酰转移酶（GGT）与基线HOMA-IR显著相关。经过12周的训练计划后，TG、SUA和GGT的变化与HOMA-IR的变化显著相关。除了它们的直接关联外，我们还观察到TG和SUA的变化与HOMA-IR的变化之间存在协同关联。根据TG和SUA的变化将参与者分为三组（三分位数）。在TG下降最大的三分位数组中，SUA变化的三分位数与HOMA-IR的变化显著相关（r = 0.525，p = 0.001），但在TG变化的其他两个三分位数组中不相关（r = 0.049，p = 0.699）。SUA和TG对HOMA-IR的变化存在显著交互作用（β = 0.281，p = 0.005）。这些结果表明，在社区老年女性进行12周步行锻炼计划后，TG和SUA的变化是与胰岛素抵抗变化相关的协同因素。
