van Roost D, Gybels J
Neurochirurgische Universitätsklinik, Bonn, Federal Republic of Germany.
Acta Neurochir Suppl (Wien). 1989;46:69-72. doi: 10.1007/978-3-7091-9029-6_17.
The literature on myelotomy for the treatment of chronic pain was reviewed and a total of 635 published cases scrutinized. Two main modes of myelotomy can be distinguished 1) a longitudinal commissural section tuned to the segmental pain level and 2) a focused central lesion, irrespective of considerations of the metameric pain distribution, mainly carried out at a high cervical level. Of the longitudinal commissural myelotomy, a posteriorly restricted and a complete type can moreover be discerned. The pain relief decays with time after myelotomy of any kind. Central myelotomy scores better than complete commissural section for malignant pain in a statistically significant manner but its superiority over posterior commissurotomy cannot be statistically proven. Except of a girdle-shaped hypo-algesia, which is expected after the section of the decussating spinothalamic fibers in a complete commissurotomy, other--irregular--patterns of hypo-algesia have been observed, especially after central myelotomy. This unusual lesion, provoking unusual hypo-algesia patterns, together with phenomena like a preserved sharp-blunt-discrimination within the hypo-algesic area, points at a different sensory channel that might be severed in a central myelotomy as compared with an anterolateral chordotomy or a complete commissurotomy. This hypothesis is matched with recent physiological evidences.
对有关脊髓切开术治疗慢性疼痛的文献进行了综述,并仔细研究了总共635例已发表的病例。脊髓切开术主要可分为两种模式:1)根据节段性疼痛水平进行的纵向连合部切开;2)聚焦性中央损伤,无论节段性疼痛分布如何,主要在高颈段进行。在纵向连合部脊髓切开术中,还可区分出后限型和完全型。任何类型的脊髓切开术后,疼痛缓解都会随着时间而减弱。对于恶性疼痛,中央脊髓切开术在统计学上比完全性连合部切开效果更好,但其相对于后连合部切开术的优势无法从统计学上得到证实。除了在完全性连合部切开术中切断交叉的脊髓丘脑纤维后预期会出现的带状痛觉减退外,还观察到了其他不规则的痛觉减退模式,尤其是在中央脊髓切开术后。这种引发异常痛觉减退模式的异常损伤,连同在痛觉减退区域内保留的锐钝辨别等现象,表明与前外侧脊髓切断术或完全性连合部切开术相比,中央脊髓切开术可能切断了不同的感觉通道。这一假设与最近的生理学证据相符。