酒精依赖受试者的一个失调亚群。
A dysbiotic subpopulation of alcohol-dependent subjects.
作者信息
de Timary Philippe, Leclercq Sophie, Stärkel Peter, Delzenne Nathalie
机构信息
a Department of Adult Psychiatry ; Institute of Neuroscience; Université catholique de Louvain ; Brussels , Belgium.
b Mc Master Brain Body Institute at St Joseph's Healthcare ; Hamilton , Ontario , Canada.
出版信息
Gut Microbes. 2015;6(6):388-91. doi: 10.1080/19490976.2015.1107696.
The vast majority of studies that assessed the importance of biological factors for the development of psychiatric disorders focused on processes occurring at the brain level. Alcohol-dependence is a very frequent psychiatric disorder where psycho-pharmacological interventions are only of moderate efficacy. Our laboratory has recently described that a subpopulation of alcohol-dependent subjects, that accounted for approximately 40% of individuals tested, presented with an increased intestinal permeability, with a dysbiosis, with alterations in the metabolomic content of faeces--that could play a role in the increased permeability--and finally with a more severe profile of alcohol-dependence than the other non-dysbiotic subpopulation. In this addendum, we discuss the implications of our observations for the pathophysiology of alcohol dependence where we try to discriminate which addiction dimensions are likely related to the gut microbiota alterations and whether these alterations are the cause or the consequence of drinking habits.
绝大多数评估生物学因素对精神疾病发展重要性的研究都集中在大脑层面发生的过程。酒精依赖是一种非常常见的精神疾病，心理药理学干预的疗效仅为中等。我们实验室最近描述了，在酒精依赖受试者的一个亚群中（约占所测试个体的40%），肠道通透性增加，存在生态失调，粪便代谢组含量发生改变（这可能在通透性增加中起作用），最后，与其他非生态失调亚群相比，该亚群的酒精依赖症状更严重。在本附录中，我们讨论了我们的观察结果对酒精依赖病理生理学的影响，我们试图区分哪些成瘾维度可能与肠道微生物群改变有关，以及这些改变是饮酒习惯的原因还是结果。
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