Middeldorp C M
Tijdschr Psychiatr. 2015;57(12):876-80.
Much of the research is focused on the role that genetic factors play in the development of psychiatric disorders during childhood and adolescence.
To present an overview of the heritability of these disorders and to describe the current state of the search for specific genetic variants.
The results of (mainly) Dutch studies in this area are summarised.
It is estimated that about 60-70% of externalising symptoms and about 40-50% of internalising symptoms are heritable. No genes have yet been identified which influence psychiatric disorders in children. It is clear, however, that even in children, psychiatric symptoms are polygenic, i.e. influenced by many genetic variants, each having a small effect.
Research on the role of genetic factors is advancing rapidly even in child psychiatry. When sample sizes are enlarged, it should be possible to identify genetic variants.
许多研究聚焦于遗传因素在儿童和青少年精神疾病发展过程中所起的作用。
概述这些疾病的遗传力，并描述寻找特定基因变异的当前状况。
总结（主要是）该领域荷兰研究的结果。
据估计，约60 - 70%的外化症状和约40 - 50%的内化症状是可遗传的。尚未发现影响儿童精神疾病的基因。然而，很明显，即使在儿童中，精神症状也是多基因的，即受许多基因变异影响，每个变异的作用都很小。
即使在儿童精神病学领域，关于遗传因素作用的研究也在迅速推进。当样本量扩大时，应该有可能识别出基因变异。
