Ilisić Tamara, Parezanović Vojislav, Ilić Slobodan, Djukić Milan, Vukomanović Goran, Vulićević Irena, Kalanj Jasna, Mimić Branko, Milovanović Vladimir, Stefanović Igor, Jovanović Ida
Srp Arh Celok Lek. 2015 Sep-Oct;143(9-10):559-66. doi: 10.2298/sarh1510559i.
Diagnosis of neonatal coarctation of the aorta (CoA) still presents a challenge in routine practice because of absence of reliable morphologic and functional parameters for early detection of this congenital heart defect in newborns.
The aim of this study is to identify easy obtainable two-dimensional echocardiographic parameters for detection of the CoA in newborns.
Echocardiographic evaluation was performed in 30 newborns with CoA and 20 healthy neonates (control group). Measurements of the proximal transverse arch (PTA), distal transverse arch (DTA), isthmus, distance between the left common carotid artery (LCCA) at the origin of the left subclavian artery (LSA), were obtained by two-dimensional echocardiography. Aortic arch hypoplasia was defined using Mouleart, Karl and Mee criteria, and Z-value. Index 1 was calculated as a ratio of DTA and distance between origins LCCA-LSA, Index 2 was calculated as a ratio of the ascending aorta and the distance between LCCA-LSA origins, and Index 3 was calculated as a ratio of PTA and distance between LCCA-LSA origins.
Index 1 was significantly lower in patients with CoA in comparison with control group (0.50 vs. 1.39; p≤0.01). A cut-off point at 0.39, for Index 1, showed a sensitivity of 92% and specificity of 99% for the diagnosis of neonatal CoA, while cut off points at 0.69 and 0.44, for Index 2 and Index 3, showed the highest sensitivity and specificity for the diagnosis of CoA in newborns.
By using these echo indexes, two-dimensional echocardiographic aortic arch measurement becomes a simple, reliable noninvasive method for the evaluation of aortic coarctation in newborns and may lead to earlier diagnosis and subsequent surgical correction.
由于缺乏用于早期检测新生儿先天性心脏缺陷的可靠形态学和功能参数,在常规实践中,新生儿主动脉缩窄(CoA)的诊断仍然是一项挑战。
本研究的目的是确定易于获得的二维超声心动图参数,用于检测新生儿的CoA。
对30例患有CoA的新生儿和20例健康新生儿(对照组)进行了超声心动图评估。通过二维超声心动图测量近端横弓(PTA)、远端横弓(DTA)、峡部、左锁骨下动脉(LSA)起始处左颈总动脉(LCCA)之间的距离。使用Mouleart、Karl和Mee标准以及Z值定义主动脉弓发育不全。指数1计算为DTA与LCCA-LSA起始处之间距离的比值,指数2计算为升主动脉与LCCA-LSA起始处之间距离的比值,指数3计算为PTA与LCCA-LSA起始处之间距离的比值。
与对照组相比,CoA患者的指数1显著降低(0.50对1.39;p≤0.01)。指数1的截断点为0.39,对新生儿CoA诊断的敏感性为92%,特异性为99%,而指数2和指数3的截断点分别为0.69和0.44时,对新生儿CoA诊断的敏感性和特异性最高。
通过使用这些超声心动图指数,二维超声心动图主动脉弓测量成为评估新生儿主动脉缩窄的一种简单、可靠的非侵入性方法,可能导致早期诊断及随后的手术矫正。