Choi Jae Yong, Lyoo Chul Hyoung, Lee Jae Hoon, Cho Hanna, Kim Kyeong Min, Kim Jin Su, Ryu Young Hoon
Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Mol Imaging Biol. 2016 Aug;18(4):479-82. doi: 10.1007/s11307-015-0924-7.
[(18)F]AV-1451 is a positron emission tomography (PET) radioligand for detecting paired helical filament tau. Our aim was to estimate the radiation dose of [(18)F]AV-1451 in humans.
Whole-body PET scans were acquired for six healthy volunteers (three male, three female) for 128 min after injection of [(18)F]AV-1451 (268 ± 31 MBq). Radiation doses were estimated using the OLINDA/EXM software.
The estimated organ doses ranged from 7.81 to 81.2 μSv/MBq. The critical organ for radiation burden was the liver. Radiation doses to the reproductive and blood-forming organs were 14.15, 8.43, and 18.35 μSv/MBq for the ovaries, testes, and red marrow, respectively. The mean effective dose was 22.47 ± 3.59 μSv/MBq.
A standard single injection of 185 MBq (5 mCi) results in an effective dose of 4.7 mSv in a healthy subject. Therefore, [(18)F]AV-1451 could be used in multiple PET scans of the same subject per year.
[18F]AV - 1451是一种用于检测配对螺旋丝tau的正电子发射断层扫描（PET）放射性配体。我们的目的是估算[18F]AV - 1451在人体中的辐射剂量。
对6名健康志愿者（3名男性，3名女性）注射[18F]AV - 1451（268±31MBq）后进行128分钟的全身PET扫描。使用OLINDA/EXM软件估算辐射剂量。
估算的器官剂量范围为7.81至81.2μSv/MBq。辐射负担的关键器官是肝脏。卵巢、睾丸和红骨髓的生殖和造血器官辐射剂量分别为14.15、8.43和18.35μSv/MBq。平均有效剂量为22.47±3.59μSv/MBq。
标准单次注射185MBq（5mCi）在健康受试者中产生的有效剂量为4.7mSv。因此，[18F]AV - 1451可用于同一受试者每年的多次PET扫描。
