Yang Chengcheng, Nan Kejun, Zhang Yamin, Chen Yimeng, Qin Sida
Department of Oncology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
Department of Oncology, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. *Corresponding author, E-mail:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Jan;32(1):84-7.
To explore the expression levels and clinical significance of cyclin D1 and estrogen receptor (ER) in breast cancer.
Immunohistochemical staining was performed to detect the expression levels of cyclin D1 and ER in 102 breast cancers and 60 normal breast tissue specimens. Referring to clinicopathological parameters and 5-year follow-up data, we analyzed the correlations between cyclin D1, ER and their prognosis.
The expression levels of both cyclin D1 and ER were significantly different between breast cancer and normal breast tissues. Cyclin D1 expression was related to tumor histological grade, TNM stage and ER levels. Spearman correlation analysis showed that cyclin D1 and ER were positively related. Moreover, Kaplan-Meier analysis showed that patients who expressed high levels of cyclin D1 had a longer overall survival compared with those with low expressions. Cyclin D1, ER, and TNM stage were independent prognosis factors according to Cox analysis.
Cyclin D1 has a higher expression in breast cancer, positively correlated with ER and better prognosis.
探讨细胞周期蛋白D1（cyclin D1）和雌激素受体（ER）在乳腺癌中的表达水平及临床意义。
采用免疫组织化学染色法检测102例乳腺癌组织和60例正常乳腺组织标本中cyclin D1和ER的表达水平。参考临床病理参数及5年随访数据，分析cyclin D1、ER与预后的相关性。
乳腺癌组织与正常乳腺组织中cyclin D1和ER的表达水平均有显著差异。Cyclin D1表达与肿瘤组织学分级、TNM分期及ER水平相关。Spearman相关性分析显示cyclin D1与ER呈正相关。此外，Kaplan-Meier分析表明，cyclin D1高表达患者的总生存期长于低表达患者。根据Cox分析，Cyclin D1、ER和TNM分期是独立的预后因素。
Cyclin D1在乳腺癌中表达较高，与ER呈正相关，预后较好。
