Mori Satoshi
Department of Bone & Joint Surgery, Seirei Hamamatsu General Hospital, Japan.
Clin Calcium. 2016 Jan;26(1):17-27.
The bone has the functions of mineral reservoir and mechanical support as skeleton. Bone remodeling is the adult mode of bone metabolism, replacing old bone tissue to new one. Bone strength is determined by bone volume, structure and quality such as micro damage, degree of mineralization and collagen cross linkage, which are all controlled by bone remodeling. Bone strength decreases under high turn-over condition by decreasing bone volume and deterioration of bone structure, which also decreases under low turn-over condition by increased micro damage, increasing mineralization and AGE collagen cross linkage.
骨骼具有作为骨架的矿物质储存和机械支撑功能。骨重塑是骨代谢的成人模式,用新的骨组织替代旧的骨组织。骨强度由骨体积、结构和质量决定,如微损伤、矿化程度和胶原交联,这些均受骨重塑控制。在高转换状态下,骨强度通过骨体积减少和骨结构恶化而降低,在低转换状态下,骨强度也会因微损伤增加、矿化增加和晚期糖基化终末产物胶原交联增加而降低。