[新研发的增强骨强度的药物]
[Newly developed drugs to improve bone strength].
作者信息
Hagino Hiroshi
机构信息
School of Health Science and Rehabilitation Division, Tottori University, Japan.
出版信息
Clin Calcium. 2016 Jan;26(1):99-105.
PMID:26728536
Abstract
Drugs for the treatment of osteoporosis improve bone strength by inhibiting bone resorption or stimulating bone formation. New drugs already using some action mechanism such as bisphosphonate or parathyroid hormone-related peptide analog are being developed in Japan. In addition, new drugs with new action mechanisms such as cathepsin K inhibitor or anti-sclerostin antibody are also being developed and it has been reported that they have good potential to increase bone mineral density.
摘要
治疗骨质疏松症的药物通过抑制骨吸收或刺激骨形成来提高骨强度。日本正在研发已采用某些作用机制的新药，如双膦酸盐或甲状旁腺激素相关肽类似物。此外，具有新作用机制的新药，如组织蛋白酶K抑制剂或抗硬化蛋白抗体也正在研发中，并且有报道称它们具有增加骨密度的良好潜力。
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