Hagino Hiroshi
School of Health Science and Rehabilitation Division, Tottori University, Japan.
Clin Calcium. 2016 Jan;26(1):99-105.
Drugs for the treatment of osteoporosis improve bone strength by inhibiting bone resorption or stimulating bone formation. New drugs already using some action mechanism such as bisphosphonate or parathyroid hormone-related peptide analog are being developed in Japan. In addition, new drugs with new action mechanisms such as cathepsin K inhibitor or anti-sclerostin antibody are also being developed and it has been reported that they have good potential to increase bone mineral density.
治疗骨质疏松症的药物通过抑制骨吸收或刺激骨形成来提高骨强度。日本正在研发已采用某些作用机制的新药，如双膦酸盐或甲状旁腺激素相关肽类似物。此外，具有新作用机制的新药，如组织蛋白酶K抑制剂或抗硬化蛋白抗体也正在研发中，并且有报道称它们具有增加骨密度的良好潜力。
