Lim Sue Zann, Ong Kong Wee, Tan Benita Kiat Tee, Selvarajan Sathiyamoorthy, Tan Puay Hoon
Department of General Surgery, Singapore General Hospital, Singapore.
Division of Surgical Oncology, National Cancer Centre Singapore, Singapore.
J Clin Pathol. 2016 May;69(5):373-81. doi: 10.1136/jclinpath-2015-203545. Epub 2016 Jan 4.
Breast sarcoma is a rare condition. It consists of a heterogeneous group of non-epithelial tumours arising from the mesenchymal tissue of the breast. It has a distinctly different natural history, treatment response and prognosis as compared with carcinoma of the breast. A different diagnostic approach and treatment strategy have to be defined for this group of tumours. Due to its rarity, the current understanding on breast sarcoma is limited and is mostly based on small retrospective case series or case reports. Hence, the management generally follows the algorithms derived from randomised control trials of soft tissue sarcomas in the extremities and chest wall. Through this review, we discuss the results of major retrospective studies on breast sarcomas including data on epidemiology, aetiology, diagnostic approach, treatment strategies and outcomes of this challenging and potentially aggressive condition.
乳腺肉瘤是一种罕见疾病。它由一组异质性的非上皮性肿瘤组成，起源于乳腺的间叶组织。与乳腺癌相比，其自然病程、治疗反应和预后明显不同。对于这组肿瘤，必须确定不同的诊断方法和治疗策略。由于其罕见性，目前对乳腺肉瘤的了解有限，大多基于小型回顾性病例系列或病例报告。因此，治疗通常遵循源自四肢和胸壁软组织肉瘤随机对照试验的算法。通过本综述，我们讨论了关于乳腺肉瘤的主要回顾性研究结果，包括这种具有挑战性且可能具有侵袭性疾病的流行病学、病因学、诊断方法、治疗策略及结果的数据。
