De Lauretis Flavia, Sanchez Alejandro Martin, Accetta Cristina, Carnassale Beatrice, D'Archi Sabatino, Di Leone Alba, Franco Antonio, Gagliardi Federica, Magno Stefano, Mason Elena Jane, Moschella Francesca, Scardina Lorenzo, Silenzi Marta, Bucaro Angela, Pirrottina Chiara V, D'Alessandris Nicoletta, Mulè Antonino, Santoro Angela, Marazzi Fabio, Masiello Valeria, Fabi Alessandra, Orlandi Armando, Palazzo Antonella, Paris Ida, Foschini Maria Pia, Masetti Riccardo, Franceschini Gianluca
Multidisciplinary Breast Center, Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Breast Surgery, Center for Women's and Newborn Health, Isola Tiberina Hospital, Gemelli Isola, 00153 Rome, Italy.
Life (Basel). 2025 Apr 20;15(4):673. doi: 10.3390/life15040673.
Mesenchymal tumors of the breast constitute a rare and heterogeneous group of neoplasms, representing only 0.5% to 1% of all breast tumors. Originating from mesenchymal tissues, these tumors include various histological subtypes. They are particularly aggressive, characterized by a high propensity for local recurrence and an overall poor prognosis. The rarity of these cases has impeded the development of comprehensive clinical studies, leading to a lack of standardized diagnostic protocols and treatment guidelines. This review provides a thorough synthesis of current knowledge on breast mesenchymal tumors with a specific focus on malignant variants such as phyllodes tumors and breast sarcomas. It also addresses the diagnostic challenges faced by clinicians, evaluates current therapeutic strategies, and emphasizes the crucial role of surgical treatment. Additionally, it examines the evolving roles of chemotherapy and radiotherapy in enhancing patient outcomes.
乳腺间叶性肿瘤是一组罕见且异质性的肿瘤，仅占所有乳腺肿瘤的0.5%至1%。这些肿瘤起源于间叶组织，包括各种组织学亚型。它们具有特别强的侵袭性，其特点是局部复发倾向高且总体预后较差。这些病例的罕见性阻碍了全面临床研究的开展，导致缺乏标准化的诊断方案和治疗指南。本综述全面综合了关于乳腺间叶性肿瘤的现有知识，特别关注叶状肿瘤和乳腺肉瘤等恶性变体。它还讨论了临床医生面临的诊断挑战，评估了当前的治疗策略，并强调了手术治疗的关键作用。此外，它还探讨了化疗和放疗在改善患者预后方面不断演变的作用。
