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PCOS in 2015: New insights into the genetics of polycystic ovary syndrome.

作者信息

Azziz Ricardo

机构信息

Medical College of Georgia, Georgia Regents University, 1120 15th Street, Augusta, Georgia 30912, USA.

出版信息

Nat Rev Endocrinol. 2016 Feb;12(2):74-5. doi: 10.1038/nrendo.2015.230. Epub 2016 Jan 4.

DOI:10.1038/nrendo.2015.230
PMID:26729036
Abstract
摘要

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Harnessing Microbiome, Bacterial Extracellular Vesicle, and Artificial Intelligence for Polycystic Ovary Syndrome Diagnosis and Management.利用微生物组、细菌细胞外囊泡和人工智能进行多囊卵巢综合征的诊断与管理。
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本文引用的文献

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Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome.从与多囊卵巢综合征的基因关联中推断出的因果机制和平衡选择
Nat Commun. 2015 Sep 29;6:8464. doi: 10.1038/ncomms9464.
2
Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.系统遗传学揭示了多囊卵巢综合征基因座的功能背景，并确定了疾病异质性的遗传和分子机制。
PLoS Genet. 2015 Aug 25;11(8):e1005455. doi: 10.1371/journal.pgen.1005455. eCollection 2015 Aug.
3
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
环境暴露与多囊卵巢综合征：综述
Semin Reprod Med. 2024 Dec;42(4):253-273. doi: 10.1055/s-0044-1801405. Epub 2025 Feb 5.
4
PCOS - the many faces of a disorder in women and men.多囊卵巢综合征——一种男女皆患疾病的多种表现形式。
J Endocrinol Invest. 2025 Apr;48(4):785-798. doi: 10.1007/s40618-024-02512-1. Epub 2024 Dec 16.
5
Causal relationship between inflammatory cytokines and polycystic ovary syndrome: a bidirectional mendelian randomization study.炎症细胞因子与多囊卵巢综合征的因果关系：一项双向孟德尔随机化研究。
J Ovarian Res. 2024 Nov 5;17(1):217. doi: 10.1186/s13048-024-01525-x.
6
Oxidative Stress in Polycystic Ovary Syndrome: Impact of Combined Oral Contraceptives.多囊卵巢综合征中的氧化应激：复方口服避孕药的影响
Antioxidants (Basel). 2024 Sep 26;13(10):1168. doi: 10.3390/antiox13101168.
7
What do we know about abnormally low prolactin levels in polycystic ovary syndrome? A narrative review.关于多囊卵巢综合征中催乳素水平异常降低我们了解多少？一项叙述性综述。
Rev Endocr Metab Disord. 2024 Dec;25(6):1127-1138. doi: 10.1007/s11154-024-09912-x. Epub 2024 Oct 19.
8
Food Cravings and Obesity in Women with Polycystic Ovary Syndrome: Pathophysiological and Therapeutic Considerations.多囊卵巢综合征女性的食物渴望和肥胖：病理生理和治疗考虑。
Nutrients. 2024 Apr 3;16(7):1049. doi: 10.3390/nu16071049.
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Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review.多囊卵巢综合征（PCOS）女性的心理症状和大脑活动改变及其与生活质量下降的关系：一项叙述性综述。
J Endocrinol Invest. 2024 Jul;47(7):1-22. doi: 10.1007/s40618-024-02329-y. Epub 2024 Mar 15.
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Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry.体质指数分层荟萃分析欧洲裔女性多囊卵巢综合征的全基因组关联研究。
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多囊卵巢综合征的全基因组关联研究表明，欧洲血统人群的促性腺激素分泌存在改变。
Nat Commun. 2015 Aug 18;6:7502. doi: 10.1038/ncomms8502.
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Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype.一种 DENND1A 异构体的过表达可导致多囊卵巢综合征的囊状卵巢表型。
Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1519-27. doi: 10.1073/pnas.1400574111. Epub 2014 Mar 31.
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Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.全基因组关联研究确定多囊卵巢综合征的 8 个新风险位点。
Nat Genet. 2012 Sep;44(9):1020-5. doi: 10.1038/ng.2384. Epub 2012 Aug 12.
6
Replication of association of DENND1A and THADA variants with polycystic ovary syndrome in European cohorts.在欧洲队列中复制 DENND1A 和 THADA 变异与多囊卵巢综合征的关联。
J Med Genet. 2012 Feb;49(2):90-5. doi: 10.1136/jmedgenet-2011-100427. Epub 2011 Dec 17.
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Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.全基因组关联研究确定了染色体 2p16.3、2p21 和 9q33.3 上多囊卵巢综合征的易感性位点。
Nat Genet. 2011 Jan;43(1):55-9. doi: 10.1038/ng.732. Epub 2010 Dec 12.
8
Genomewide association studies and human disease.全基因组关联研究与人类疾病
N Engl J Med. 2009 Apr 23;360(17):1759-68. doi: 10.1056/NEJMra0808700. Epub 2009 Apr 15.
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Heritability of polycystic ovary syndrome in a Dutch twin-family study.荷兰双胞胎家庭研究中多囊卵巢综合征的遗传度
J Clin Endocrinol Metab. 2006 Jun;91(6):2100-4. doi: 10.1210/jc.2005-1494. Epub 2005 Oct 11.