Chai Yi
The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Tumour Biol. 2016 Mar;37(3):2817-21. doi: 10.1007/s13277-015-4743-x. Epub 2016 Jan 4.
Biliary tract cancers (BTCs), which encompass intra- and extrahepatic cholangiocarcinomas as well as gallbladder carcinomas, are one of the most aggressive malignancies. Although the development of systemic chemotherapy approaches has made progress, the prognosis of BTC remains poor. Chronic inflammation plays an important role in the carcinogenesis of BTC, highlighting the immune etiology of this disease. Immunotherapy has emerged as a promising new modality of treatment for BTC. Here, we summarize the relevant tumor immunology of BTC and recently completed and ongoing clinical trials of immunotherapy for BTC.
胆道癌（BTC）包括肝内和肝外胆管癌以及胆囊癌，是最具侵袭性的恶性肿瘤之一。尽管全身化疗方法的发展取得了进展，但BTC的预后仍然很差。慢性炎症在BTC的致癌过程中起重要作用，突出了这种疾病的免疫病因。免疫疗法已成为一种有前景的BTC新治疗方式。在此，我们总结了BTC的相关肿瘤免疫学以及最近完成和正在进行的BTC免疫疗法临床试验。
