Panigrahi Mousumee, Swain Trupti Rekha, Mohanty Srikanta
Department of Pharmacology, SCB Medical College, Cuttack, Odisha, India.
Indian J Pharmacol. 2015 Nov-Dec;47(6):672-5. doi: 10.4103/0253-7613.169578.
To correlate the level of anxiety with nonadherence to antiretroviral medication.
This observational, cross-sectional, hospital-based study was conducted in 78 patients attending antiretroviral therapy (ART) center of a tertiary care hospital of Odisha. The study duration was 6 months. Patients were designated as nonadherent by referring to the white card. Utilization of ART drugs and adverse drug reactions were included in a predesigned format. The anxiety level of all included patients was scored as per Hamilton Anxiety Rating Scale. Mean anxiety score of the adherent group was compared with that of the nonadherent group. Possible causes of nonadherence leading to high anxiety level were evaluated.
46% of patients in the nonadherent group had very severe, 17% had moderate to severe, 28% had mild to moderate and 9% had a mild level of anxiety. In the adherent group, however, mild to moderate level of anxiety was observed only in 10% patients.
Anxiety is associated with sub-optimal medication adherence in HIV infected patients.
将焦虑水平与抗逆转录病毒药物治疗的不依从性进行关联分析。
本研究为一项基于医院的观察性横断面研究，纳入了奥里萨邦一家三级护理医院抗逆转录病毒治疗（ART）中心的78例患者。研究持续时间为6个月。通过查阅白卡将患者认定为不依从。以预先设计的表格形式记录ART药物的使用情况和药物不良反应。根据汉密尔顿焦虑评定量表对所有纳入患者的焦虑水平进行评分。比较依从组和不依从组的平均焦虑评分。评估导致高焦虑水平的不依从的可能原因。
不依从组中46%的患者焦虑程度非常严重，17%为中度至重度，28%为轻度至中度，9%为轻度。然而，在依从组中，仅10%的患者存在轻度至中度焦虑。
焦虑与HIV感染患者药物治疗依从性欠佳有关。
