Voundi Esther Voundi, Kalla Ginette Claude Mireille, Kenfack Joel Duplexe Tschoufack, Olen Jean Pierre Kamga, Essi Marie Josée, Mbopi-Keou Francois-Xavier
Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé I, Yaoundé, Cameroun.
Institut pour le Développement de l´Afrique (The-IDA), Yaoundé, Cameroun.
Pan Afr Med J. 2022 Apr 20;41:320. doi: 10.11604/pamj.2022.41.320.33056. eCollection 2022.
depression may be associated with poor immune and virological response, poor quality of life and high medical costs in people living with HIV. The purpose of this study is to investigate the association between depression and viral load in people living with HIV on antiretroviral treatment followed at the Yaounde Central Hospital.
we conducted a cross-sectional study of people living with HIV who had their viral load results at the Central Hospital of Yaounde over 8 months (November 2019 to July 2020). Before starting the study, informed consent was obtained from each participant. Sociodemographic, clinical, paraclinical and lifestyle data were collected. Depression was assessed using the Hospital Anxiety and Depression scale (HAD). Consecutive and non-probability sampling was used. Statistical analysis was performed using SPSS software version 23.0. A p-value < 0.05 was considered statistically significant.
of the 205 participants enrolled, female sex was the most represented (n=153, 74.6%) and the mean age was 46.5 ± 1.8 years. All participants had clinical stage I HIV and most of them had undetectable viral load (n=164, 80.0%). Definite depression was found in 4.8% of cases and people living with HIV with symptoms of definite depression were more likely to have a high viral load (OR = 14.24 [3.61-56.14]; p = <0.001). depression could be a leading cause of high viral load.
抑郁症可能与艾滋病毒感染者的免疫和病毒学反应不佳、生活质量差以及医疗费用高昂有关。本研究的目的是调查在雅温得中心医院接受抗逆转录病毒治疗的艾滋病毒感染者中抑郁症与病毒载量之间的关联。
我们对2019年11月至2020年7月在雅温得中心医院进行病毒载量检测的艾滋病毒感染者进行了一项横断面研究。在开始研究之前，获得了每位参与者的知情同意。收集了社会人口统计学、临床、辅助临床和生活方式数据。使用医院焦虑和抑郁量表（HAD）评估抑郁症。采用连续非概率抽样。使用SPSS 23.0软件进行统计分析。p值<0.05被认为具有统计学意义。
在纳入的205名参与者中，女性占比最高（n = 153，74.6%），平均年龄为46.5±1.8岁。所有参与者的HIV临床分期均为I期，且大多数人的病毒载量检测不到（n = 164，80.0%）。4.8%的病例被发现患有确诊抑郁症，有确诊抑郁症症状的艾滋病毒感染者更有可能病毒载量高（比值比 = 14.24 [3.61 - 56.14]；p = <0.001）。抑郁症可能是病毒载量高的主要原因。
