Mishra Debi Prasad, Ramamurthy Sindhu, Behera Samir Kumar
Department of Pathology, The Maharaja Krishna Chandra Gajapati Medical College, Berhampur, Odisha, India.
J Cytol. 2015 Jul-Sep;32(3):188-90. doi: 10.4103/0970-9371.168855.
Histoplasmosis is an opportunistic fungal infection caused by inhaling the spores of a fungus called Histoplasma capsulatum. Disseminated histoplasmosis is the most common form associated with acquired immune deficiency syndrome (AIDS). Here, we report a case of histoplasmosis presenting as isolated cervical lymphadenopathy in a human immunodeficiency virus (HIV)-infected patient diagnosed by a less invasive method (fine-needle aspiration cytology) and confirmed by fungal culture of fine-needle aspiration material. Due to varied and nonspecific clinical manifestations of histoplasmosis, most of the infections are misdiagnosed or underreported. It has to be considered in differential diagnosis of cervical lymphadenopathy, particularly in immunocompromised patients so that patients can be treated medically at an early stage before dissemination occurs and unnecessary surgery can be avoided. Here, we present this case because of its rare presentation as isolated cervical lymphadenopathy and classical cytological picture.
组织胞浆菌病是一种机会性真菌感染，由吸入名为荚膜组织胞浆菌的真菌孢子引起。播散性组织胞浆菌病是与获得性免疫缺陷综合征（AIDS）相关的最常见形式。在此，我们报告一例组织胞浆菌病病例，该病例表现为一名感染人类免疫缺陷病毒（HIV）的患者出现孤立性颈部淋巴结病，通过侵入性较小的方法（细针穿刺细胞学检查）诊断，并经细针穿刺材料的真菌培养确诊。由于组织胞浆菌病的临床表现多样且不具特异性，大多数感染被误诊或报告不足。在颈部淋巴结病的鉴别诊断中必须考虑到该病，尤其是在免疫功能低下的患者中，以便在疾病播散之前的早期阶段对患者进行药物治疗，并避免不必要的手术。在此，我们展示该病例是因其罕见地表现为孤立性颈部淋巴结病以及典型的细胞学图像。
