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对于一位曾患妊娠急性肝脂肪变性(席汉病)并已康复且希望再次怀孕的女性,你能给出什么建议?

[What advice can you give to a woman having survived an acute liver steatosis in pregnancy (Sheehan disease) and who wants to get pregnant again?].

作者信息

Sondag D, Reymann P

机构信息

Service de Médecine B, Hépatogastroentérologie, C.H. du Hasenrain, Mulhouse.

出版信息

Ann Gastroenterol Hepatol (Paris). 1989 May;25(3):91-5.

PMID:2672999
Abstract

The acute fatty liver of pregnancy is a rare and potentially fatal disorder, which may complicate the third trimester of pregnancy. Early recognition of the disorder with rapid termination of the pregnancy and intensive treatment have lightened an often dismal prognosis. Maternal and fetal mortality rates are about 20-30% and 50% respectively. What advice should be given to survivors if they wish to become pregnant again? After an acute fatty liver cure, it should be noted that 21 pregnancies in 17 women were concluded without complications and these resulted in the births of normal infants. To our knowledge, no recurrences of acute fatty, liver were made known. These results probably allow a more favourable view of a new pregnancy in a woman who has survived.

摘要

妊娠急性脂肪肝是一种罕见且可能致命的疾病,可在妊娠晚期并发。早期识别该疾病并迅速终止妊娠及强化治疗改善了以往通常不佳的预后。孕产妇和胎儿死亡率分别约为20% - 30%和50%。对于幸存者如果希望再次怀孕应给予什么建议呢?在妊娠急性脂肪肝治愈后,需要注意的是,17名女性的21次妊娠均无并发症,且分娩出正常婴儿。据我们所知,未发现急性脂肪肝复发的情况。这些结果可能使人们对存活下来的女性再次怀孕持更乐观的看法。

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