Logan Sarah A, Thyparampil Preeti J, Yen Michael T
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, U.S.A.
Ophthalmic Plast Reconstr Surg. 2017 May-Jun;33(3S Suppl 1):S58-S60. doi: 10.1097/IOP.0000000000000615.
Solid organ transplantation is the preferred method of treatment for a number of advanced medical conditions, but it requires systemic immunosuppression to prevent transplant rejection. The authors report 2 unique cases of persistent eyelid edema following solid organ transplantation believed to be related to their systemic immunosuppression. The eyelid findings developed after initiation of the immunosuppressant sirolimus. In 1 patient, the eyelid edema has persisted despite discontinuation of the medication. In the second patient, the immunosuppression could not be altered; therefore, he underwent surgical excision of the edematous lower eyelid. Sirolimus associated eyelid edema is an important medication side effect for ophthalmic and eyelid specialists to consider when a patient with a history of organ transplantation presents with localized noninflamed eyelid edema. This edema can persist despite discontinuation of the medication. Surgical excision of the edematous eyelid can achieve good results.
实体器官移植是多种晚期疾病的首选治疗方法，但需要全身免疫抑制以防止移植排斥反应。作者报告了2例实体器官移植后持续眼睑水肿的独特病例，认为这与全身免疫抑制有关。眼睑症状在开始使用免疫抑制剂西罗莫司后出现。在1例患者中，尽管停药，眼睑水肿仍持续存在。在第2例患者中，无法改变免疫抑制状态；因此，他接受了手术切除水肿的下眼睑。对于有器官移植史且出现局部非炎症性眼睑水肿的患者，西罗莫司相关的眼睑水肿是眼科和眼睑专科医生需要考虑的重要药物副作用。尽管停药，这种水肿仍可能持续存在。手术切除水肿的眼睑可取得良好效果。
