基于两名血友病患者的初步研究对家庭治疗所需凝血因子 VIII 的预测估计。

Projected estimation of factor VIII requirements for home treatment based on a pilot study of two haemophilic patients.

作者信息

Davies S H

出版信息

Scand J Haematol Suppl. 1977;30:87-9. doi: 10.1111/j.1600-0609.1977.tb01531.x.

DOI:10.1111/j.1600-0609.1977.tb01531.x

Abstract

An extensive programme of home administration of factor VIII replacement therapy has been proposed for the haemophiliacs of the Edinburgh Area following the successful training of self-administration therapy in the Haemophilia Centre. A study of 1 moderate and 1 severe haemophiliac, whose factor VIII requirements for the year 1974 were compared with factor VIII usage for "on demand" out-patient therapy at the Centre in 1973, showed these quantities to be 14,380 as compared with 38,725 factor VIII units in the severely affected patient. From these figures, and, knowing that the average number of factor VIII units used per patient per years was 8,116 for the moderate and 11,592 for the severe haemophiliacs, it has been calculated that home treatment would require 6,000-10,000 factor VIII units per patient per year for the latter class. The advantages and hazards of home treatment are discussed and evaluated in the light of the two patients studied and the self-administration programme of therapy at present in operation.

摘要

在血友病中心成功开展自我给药治疗培训后，已为爱丁堡地区的血友病患者提出了一项广泛的在家进行因子 VIII 替代疗法给药的计划。对 1 名中度血友病患者和 1 名重度血友病患者进行了研究，将他们 1974 年的因子 VIII 需求量与 1973 年在该中心“按需”门诊治疗时的因子 VIII 使用量进行了比较，结果显示，重度患者的这两个量分别为 14,380 和 38,725 因子 VIII 单位。根据这些数字，并且已知中度血友病患者每年人均使用因子 VIII 单位数为 8,116，重度血友病患者为 11,592，据此计算出，对于后一类患者，在家治疗每年每人需要 6,000 - 10,000 因子 VIII 单位。根据所研究的两名患者以及目前正在实施的自我给药治疗计划，对在家治疗的利弊进行了讨论和评估。