Zhou Qiancheng, Hu Hong-Gang, Hou Lingling
Clin Lab. 2015;61(11):1589-99. doi: 10.7754/clin.lab.2015.150332.
Tumor biomarkers can serve as tools for early detection, diagnosis, prognosis, therapeutic target, response predicting, therapy monitoring of tumors or can be used as surrogate endpoints. Their abilities to assist various clinical decisions make them indispensable tools for current oncotherapies. Therefore, in the past decades, significant effort has been put into finding sensitive, specific, noninvasive, inexpensive, and clinically feasible tumor biomarkers. This review will summarize the recent progress made in different kinds of tumor biomarkers, introduce a promising and versatile novel tumor biomarker called DEK oncoprotein, and lastly, discuss the prospects of tumor biomarkers.
肿瘤生物标志物可作为肿瘤早期检测、诊断、预后评估、治疗靶点、疗效预测、治疗监测的工具，或用作替代终点。它们协助进行各种临床决策的能力使其成为当前肿瘤治疗中不可或缺的工具。因此，在过去几十年里，人们付出了巨大努力来寻找敏感、特异、无创、廉价且临床可行的肿瘤生物标志物。本综述将总结不同类型肿瘤生物标志物的最新进展，介绍一种有前景且多功能的新型肿瘤生物标志物——DEK癌蛋白，最后讨论肿瘤生物标志物的前景。
