Aguirre Marina, Manzano Natalia, Salas Yésica, Angel Martín, Díaz-Couselo Fernando A, Zylberman Marcelo
Instituto Alexander Fleming, Crámer 1180, Ciudad de Buenos Aires, Argentina.
Arch Osteoporos. 2016;11:4. doi: 10.1007/s11657-015-0256-x. Epub 2016 Jan 5.
A high prevalence of hypovitaminosis D has been reported in cancer patients. Low levels of 25-(OH)-vitamin D were found in 158 of 162 (97.5%) inpatients with breast, lung, and colorectal cancer under active treatment, with severe deficiency (<20 ng/ml) in 77.2% and mild deficiency (20-30 ng/ml) in 20.4%.
A high prevalence of vitamin D deficiency has been reported in cancer patients. Nevertheless, vitamin D serum levels have been checked in few patients. Information about the frequency of hypovitaminosis D in cancer patients in Argentina is unknown. The aim of the study was to assess the frequency of vitamin D deficiency in patients with breast, lung, and colorectal cancer.
A prospective observational study was designed for cancer patients admitted to the general ward in 2014. The patients included had breast, lung, and colorectal cancer. All of them were under active treatment. The serum level of 25-(OH)-vitamin D [25-(OH)-D] was measured and categorized as sufficiency (>30 ng/ml), mild deficiency (20-30 ng/ml), and severe deficiency (<20 ng/ml).
A total of 162 patients were included, 98.2% were in stages III-IV. Median level of 25-(OH)-D was 15.3 ng/ml (range 4.1-103.6 ng/ml). Serum levels <30 ng/ml were found in 158 (97.5%) patients, severe deficiency in 125 cases (77.2%) and mild deficiency in 33 cases (20.4%). In patients under chemo/hormone therapy, the median level was 15.3 ng/ml (range 4.1-103.6 ng/ml) and in those under concurrent therapy was 17.1 ng/ml (range 7.4-58.5 ng/ml); p = 0.1944. There were no statistical differences in severe or mild deficiency of vitamin D among breast, lung, and colorectal cancer patients.
The study found a high prevalence of vitamin D deficiency in hospitalized cancer patients under active treatment. Many authors have recommended dosing vitamin D levels in this population; normalizing serum levels is difficult.
据报道，癌症患者中维生素D缺乏症的患病率很高。在162例正在接受积极治疗的乳腺癌、肺癌和结直肠癌住院患者中，有158例（97.5%）的25-（OH）-维生素D水平较低，其中77.2%为严重缺乏（<20 ng/ml），20.4%为轻度缺乏（20 - 30 ng/ml）。
据报道，癌症患者中维生素D缺乏症的患病率很高。然而，对少数患者进行了维生素D血清水平检测。阿根廷癌症患者中维生素D缺乏症的发生频率尚无相关信息。本研究的目的是评估乳腺癌、肺癌和结直肠癌患者中维生素D缺乏症的发生频率。
设计了一项前瞻性观察性研究，针对2014年入住普通病房的癌症患者。纳入的患者患有乳腺癌、肺癌和结直肠癌。他们均在接受积极治疗。测量血清25-（OH）-维生素D[25-（OH）-D]水平，并分类为充足（>30 ng/ml）、轻度缺乏（20 - 30 ng/ml）和严重缺乏（<20 ng/ml）。
共纳入162例患者，98.2%处于III - IV期。25-（OH）-D的中位水平为15.3 ng/ml（范围4.1 - 103.6 ng/ml）。158例（97.5%）患者的血清水平<30 ng/ml，125例（77.2%）为严重缺乏，33例（20.4%）为轻度缺乏。接受化疗/激素治疗的患者中位水平为15.3 ng/ml（范围4.1 - 103.6 ng/ml），接受同步治疗的患者中位水平为17.1 ng/ml（范围7.4 - 58.5 ng/ml）；p = 0.1944。乳腺癌、肺癌和结直肠癌患者中维生素D严重或轻度缺乏情况无统计学差异。
该研究发现，正在接受积极治疗的住院癌症患者中维生素D缺乏症的患病率很高。许多作者建议对该人群的维生素D水平进行检测；使血清水平正常化很困难。
