Huhtaniemi Ilpo
Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, London, UK; and Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland.
Hormones (Athens). 2015 Oct-Dec;14(4):468-78. doi: 10.14310/horm.2002.1632.
It is well established in various experimental models that luteinizing hormone (LH) stimulated testosterone (T) production of Leydig cells is the key endocrine stimulus of spermatogenesis. The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshr knockout mice, maintain fairly normal spermatogenesis and fertility. Furthermore, FSH treatment of male infertility has produced at best modest results. On the other hand, there are animal species (e.g. teleost fishes and the Djungarian hamster) where spermatogenesis is primarily FSH-dependent. The purpose of this article is to briefly review the gonadotrophin dependence of spermatogenesis in several model species and examine how it has shifted during evolution from FSH to LH dominance. The information may provide new insight into the role of FSH treatment of male infertility.
在各种实验模型中已经明确，促黄体生成素（LH）刺激睾丸间质细胞产生睾酮（T）是精子发生的关键内分泌刺激因素。另一种促性腺激素，即促卵泡生成素（FSH）的作用尚不完全清楚，因为包括携带失活FSH受体（R）突变的男性以及雄性Fshb和Fshr基因敲除小鼠在内的多种临床情况和实验模型，都维持着相当正常的精子发生和生育能力。此外，FSH治疗男性不育症的效果充其量也只是一般。另一方面，在一些动物物种（如硬骨鱼类和黑线毛足鼠）中，精子发生主要依赖FSH。本文的目的是简要回顾几种模型物种中精子发生对促性腺激素的依赖性，并探讨其在进化过程中是如何从以FSH为主转变为以LH为主的。这些信息可能为FSH治疗男性不育症的作用提供新的见解。
