Lorenzo M, Fabregat I, Benito M
Departamento e Bioquímica y Biología Molecular, Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.
Biochem Biophys Res Commun. 1989 Aug 30;163(1):341-7. doi: 10.1016/0006-291x(89)92141-4.
Insulin increased malic enzyme activity and protein content in foetal brown adipocyte primary cultures through a two fold increase in the rates of enzyme synthesis. Conversely, noradrenaline prevented the induction caused by insulin on enzyme expression through an accelerate rate of malic enzyme degradation. Tri-iodothyronine had no effect on the expression of malic enzyme in cultured foetal brown adipocytes.
胰岛素通过使酶合成速率提高两倍，增加了胎儿棕色脂肪细胞原代培养物中苹果酸酶的活性和蛋白质含量。相反，去甲肾上腺素通过加速苹果酸酶的降解速率，阻止了胰岛素对酶表达的诱导作用。三碘甲状腺原氨酸对培养的胎儿棕色脂肪细胞中苹果酸酶的表达没有影响。
