Arzneimittelforschung. 1989 Jun;39(6):724-7.
Pharmacokinetic data and analgetic potency of nalbuphine hydrochloride (Nubain) under conditions of postoperative respiratory treatment and repeated dosage was investigated in a multicenter study. Patients received 20 mg nalbuphine intravenously at intervals of 3 h. Blood samples for analysis of nalbuphine plasma concentration were taken after the first injection, immediately before further medication and after the last one. Data were fitted to 2-compartment model using non-linear fit procedures. The half-life time in plasma was slightly shorter than in other studies, while the peak plasma concentrations were comparable with other results in the literature. There was no cumulation of the substance found in this study. Clinically the antagonistic effect of nalbuphine was mainly observed after neuroleptic anaesthesia. In these cases additional injections of further analgetic and sedative drugs were necessary. The clinical effect was mostly considered to be good or satisfactory. Less satisfactory effects were due to the 3 h time distance between repeated dosage. Shorter intervals could be discussed and used because of the absence of cumulation of nalbuphine in this study.
在一项多中心研究中，对盐酸纳布啡（纳布啡）在术后呼吸治疗及重复给药条件下的药代动力学数据和镇痛效力进行了研究。患者每隔3小时静脉注射20毫克纳布啡。在首次注射后、再次给药前即刻以及最后一次注射后采集血样以分析纳布啡血浆浓度。数据采用非线性拟合程序拟合到二室模型。血浆中的半衰期略短于其他研究，而血浆峰值浓度与文献中的其他结果相当。本研究中未发现该物质有蓄积现象。临床上，纳布啡的拮抗作用主要在神经安定麻醉后观察到。在这些情况下，需要额外注射其他镇痛和镇静药物。临床效果大多被认为良好或令人满意。效果不太令人满意是由于重复给药间隔为3小时。鉴于本研究中纳布啡无蓄积现象，可探讨并采用更短的间隔时间。
