Lehner Barbara, Eichelberger Beate, Jungbauer Christof, Panzer Simon
Department of Blood Group Serology and Transfusion Medicine, Medical University Vienna, Vienna, Austria.
Vienna Blood Center, Blood Service, Austrian Red Cross, Vienna, Austria.
Transfus Med Hemother. 2015 Nov;42(6):366-71. doi: 10.1159/000432414. Epub 2015 Jun 18.
The extent of expression of the blood group A on platelets is controversial. Further, the relation between platelets' blood group A expression and the titers of isoagglutinins has not been thoroughly investigated, so far.
We evaluated the relation between the genotype with platelets' blood group A and H expression estimated by flow cytometry and the titers of isoagglutinins.
The A expression varied between genotypes and within genotypes. However, the expression in A1 was stronger than in all other genotypes (p < 0.0001). An overlap of expression levels was apparent between homozygous A1A1 and heterozygous A1 individuals. Still, The A1A1 genotype is associated with a particularly high antigen expression (p = 0.009). Platelets' A expression in A2 versus blood group O donors was also significant (p = 0.007), but there was again an overlap of expression. The secretor status had only little influence on the expression (p = 0.18). Also, isoagglutinin titers were not associated with genotypes.
To distinguish between A1 and A2 donors may reduce incompatible platelet transfusions and therefore be favorable on platelet transfusion increment. Clinical data are needed to support this notion.
血小板上A血型的表达程度存在争议。此外，血小板A血型表达与同种凝集素滴度之间的关系迄今尚未得到充分研究。
我们评估了通过流式细胞术估计的血小板A血型和H表达的基因型与同种凝集素滴度之间的关系。
A表达在不同基因型之间以及同一基因型内部存在差异。然而，A1型中的表达强于所有其他基因型（p < 0.0001）。纯合子A1A1和杂合子A1个体之间的表达水平存在明显重叠。尽管如此，A1A1基因型与特别高的抗原表达相关（p = 0.009）。A2型与O型血供者的血小板A表达也有显著差异（p = 0.007），但表达同样存在重叠。分泌状态对表达的影响很小（p = 0.18）。此外，同种凝集素滴度与基因型无关。
区分A1和A2供者可能会减少不相容的血小板输注，因此有利于提高血小板输注量。需要临床数据来支持这一观点。
