HPV 相关癌症中的 HPV-p53-miR-34a 轴。
HPV-p53-miR-34a axis in HPV-associated cancers.
机构信息
1 School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia ; 2 Institute of Molecular Virology and Immunology, Department of Medical Microbiology and Immunology, Wenzhou Medical University, Wenzhou 325000, China ; 3 Centre for Kidney Disease Research-Venomics Research, School of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD 4102, Australia.
出版信息
Ann Transl Med. 2015 Dec;3(21):331. doi: 10.3978/j.issn.2305-5839.2015.09.39.
Human papillomaviruses (HPVs) are known to cause many cancers by altering multiple signalling pathways through their oncogene integration into host genome and expression. Studies have shown that many microRNAs (miRs) may function as oncogenes (called as oncomiRs) to promote an oncogenic effect. MiR-34a among the reported oncomiRs is a key player in the carcinogenesis caused by infection with HPVs. In this mini-review, we summarise the roles of miR-34a in HPV-caused cancers. MiR-34a is transcriptionally regulated by tumour suppressor p53. HPV oncogene E6 inhibits expression of p53 to decrease the levels of miR-34a, leading to the increased expression of multiple genes which are targeted by miR-34a. The upregulation of these genes increases cancer cell proliferation, survival and migration in HPV-associated cancers.
人乳头瘤病毒（HPV）通过其致癌基因整合到宿主基因组和表达，改变多种信号通路而被认为可导致多种癌症。研究表明，许多 microRNA（miR）可能作为致癌基因（称为致癌 miR）发挥作用，从而促进致癌作用。在报道的致癌 miR 中，miR-34a 是 HPV 感染引起的癌变的关键参与者。在这篇迷你综述中，我们总结了 miR-34a 在 HPV 引起的癌症中的作用。miR-34a 受肿瘤抑制因子 p53 的转录调控。HPV 致癌基因 E6 抑制 p53 的表达，从而降低 miR-34a 的水平，导致多个 miR-34a 靶向的基因表达增加。这些基因的上调增加了 HPV 相关癌症中癌细胞的增殖、存活和迁移。
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