伊朗自身免疫性肝炎患者的白细胞介素4基因多态性
IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis.
作者信息
Yousefi Azizollah, Mahmoudi Elham, Zare Bidoki Alireza, Najmi Varzaneh Farnaz, Baradaran Noveiry Behnoud, Sadr Maryam, Motamed Farzaneh, Najafi Mehri, Farahmand Fatemeh, Rezaei Nima
机构信息
a Department of Gastroenterology, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
b Molecular Immunology Research Center; Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
出版信息
Expert Rev Gastroenterol Hepatol. 2016;10(5):659-63. doi: 10.1586/17474124.2016.1139449. Epub 2016 Feb 11.
BACKGROUND
Autoimmune hepatitis (AIH) is a chronic long-lasting hepatocellular inflammation associated with circulating auto antibodies. In addition to the genetic component, several cytokines have been implicated to be involved in AIH. This study was performed to investigate potential associations of AIH with IL4 gene variants.
METHOD
The studied alleles and genotypes included: IL4G/T allele polymorphisms at position -1098 and C/T allele polymorphisms at two positions (-33 and -590) on the IL4 gene, in addition to the A/G allele polymorphisms at position +1902 on the IL4RA gene.
RESULT
The IL4 C allele and CC genotype at position -590 and TT genotype at position -33 had a significantly higher frequency in AIH patients.
CONCLUSION
This study identified the IL4 C allele and CC genotype susceptibility gene in AIH, which will provide better insights into the mechanisms of AIH and potential therapeutic interventions.
背景
自身免疫性肝炎（AIH）是一种与循环自身抗体相关的慢性持续性肝细胞炎症。除了遗传因素外，多种细胞因子也被认为与AIH有关。本研究旨在探讨AIH与白细胞介素4（IL4）基因变异之间的潜在关联。
方法
研究的等位基因和基因型包括：IL4基因-1098位点的IL4G/T等位基因多态性、IL4基因两个位点（-33和-590）的C/T等位基因多态性，以及IL4受体A（IL4RA）基因+1902位点的A/G等位基因多态性。
结果
AIH患者中，IL4基因-590位点的C等位基因和CC基因型以及-33位点的TT基因型频率显著更高。
结论
本研究确定了AIH中IL4 C等位基因和CC基因型的易感基因，这将为深入了解AIH的发病机制和潜在治疗干预提供更好的见解。
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