Assari Raheleh, Aghighi Yahya, Ziaee Vahid, Sadr Maryam, Rezaei Arezou, Rahmani Farzaneh, Sadr Zeinab, Raeeskarami Seyed Reza, Moradinejad Mohammad Hassan, Rezaei Nima
Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran, Iran.
Department of Pediatrics, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
Int J Rheum Dis. 2018 Jan;21(1):266-270. doi: 10.1111/1756-185X.12968. Epub 2016 Dec 30.
Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD.
Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions -1098 (rs2243248), -590 (rs2243250) and -33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group.
The C allele and CC genotype of IL-4 gene at position -590 and at position -33 had positive associations and the CT genotype at -590 was negatively associated with KD (odds ratio (95% CI) = 0.04 [0.01-0.09]). The haplotype TCC was more frequent among the patients, while the haplotypes TTT and TTC had a negative association with KD.
IL-4 polymorphisms might be associated with KD in an Iranian population.
川崎病（KD）是一种中等大小动脉的系统性血管炎。白细胞介素4（IL-4）水平升高和Th2细胞因子占优势似乎是KD急性期的一个关键特征。在本研究中，对伊朗KD患儿中IL-4和IL-4R基因多态性的作用进行了研究。
本研究纳入了55例KD患者和140名健康受试者作为对照组。对患者和对照组评估了IL-4基因在-1098（rs2243248）、-590（rs2243250）和-33（rs2070874）位置的单核苷酸多态性（SNP），以及IL-4RA基因在+1902（rs180275）位置的SNP。
IL-4基因在-590和-33位置的C等位基因和CC基因型与KD呈正相关，-590位置的CT基因型与KD呈负相关（优势比（95%可信区间）=0.04[0.01-0.09]）。单倍型TCC在患者中更常见，而单倍型TTT和TTC与KD呈负相关。
在伊朗人群中，IL-4多态性可能与KD有关。
