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Take two: Combining immunotherapy with epigenetic drugs to tackle cancer.

作者信息

Weintraub Karen

出版信息

Nat Med. 2016 Jan;22(1):8-10. doi: 10.1038/nm0116-8.

DOI:10.1038/nm0116-8
PMID:26735398
Abstract
摘要

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Take two: Combining immunotherapy with epigenetic drugs to tackle cancer.尝试二:联合免疫疗法与表观遗传药物对抗癌症。
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Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer.联合表观遗传学治疗对难治性晚期非小细胞肺癌患者有效。
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Combining targeted agents in lung cancer.肺癌中靶向药物的联合应用。
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Addressing the elephant in the room, therapeutic resistance in non-small cell lung cancer, with epigenetic therapies.直面房间里的大象——非小细胞肺癌的治疗耐药性,采用表观遗传疗法。
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Lung cancer: Squiring immunotherapy to CheckMate.肺癌:为“纳武利尤单抗”配备免疫疗法
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Onartuzumab ineffective in non-small-cell lung cancer.奥那珠单抗对非小细胞肺癌无效。
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Cells. 2024 Dec 31;14(1):31. doi: 10.3390/cells14010031.
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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade.克服癌症中的免疫抑制:生酮饮食如何增强免疫检查点阻断。
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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.抑制DNA甲基化会通过包括内源性逆转录病毒在内的双链RNA在癌症中引发干扰素反应。
Cell. 2015 Aug 27;162(5):974-86. doi: 10.1016/j.cell.2015.07.011.
2
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.DNA去甲基化剂通过诱导内源性转录本产生病毒模拟来靶向结肠直肠癌细胞。
Cell. 2015 Aug 27;162(5):961-73. doi: 10.1016/j.cell.2015.07.056.
3
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
内源性逆转录病毒的表观遗传调控:对癌症免疫治疗的影响
Genes Genomics. 2024 Nov;46(11):1303-1312. doi: 10.1007/s13258-024-01546-2. Epub 2024 Aug 1.
4
Ketogenic Diet Alters the Epigenetic and Immune Landscape of Prostate Cancer to Overcome Resistance to Immune Checkpoint Blockade Therapy.生酮饮食改变前列腺癌的表观遗传和免疫景观,以克服对免疫检查点阻断治疗的耐药性。
Cancer Res. 2024 May 15;84(10):1597-1612. doi: 10.1158/0008-5472.CAN-23-2742.
5
Treatment of refractory/relapsed extranodal NK/T cell lymphoma with decitabine plus anti-PD-1: A case report.地西他滨联合抗PD-1治疗难治性/复发性结外NK/T细胞淋巴瘤:一例报告
World J Clin Cases. 2022 Oct 6;10(28):10193-10200. doi: 10.12998/wjcc.v10.i28.10193.
6
The correlation of EZH2 expression with the progression and prognosis of hepatocellular carcinoma.EZH2 表达与肝细胞癌进展和预后的相关性。
BMC Immunol. 2022 Jun 4;23(1):28. doi: 10.1186/s12865-022-00502-7.
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A New Trend in Cancer Treatment: The Combination of Epigenetics and Immunotherapy.癌症治疗新趋势:表观遗传学与免疫疗法的联合。
Front Immunol. 2022 Jan 24;13:809761. doi: 10.3389/fimmu.2022.809761. eCollection 2022.
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Insights into the therapeutic potential of histone deacetylase inhibitor/immunotherapy combination regimens in solid tumors.深入了解组蛋白去乙酰化酶抑制剂/免疫疗法联合方案在实体瘤中的治疗潜力。
Clin Transl Oncol. 2022 Jul;24(7):1262-1273. doi: 10.1007/s12094-022-02779-x. Epub 2022 Jan 23.
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Endogenous retroviruses in the origins and treatment of cancer.内源性逆转录病毒在癌症的起源和治疗中的作用。
Genome Biol. 2021 May 10;22(1):147. doi: 10.1186/s13059-021-02357-4.
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Improved clinical outcome in a randomized phase II study of anti-PD-1 camrelizumab plus decitabine in relapsed/refractory Hodgkin lymphoma.抗 PD-1 单抗卡瑞利珠单抗联合地西他滨治疗复发/难治性霍奇金淋巴瘤的随机 II 期研究中改善了临床结局。
J Immunother Cancer. 2021 Apr;9(4). doi: 10.1136/jitc-2021-002347.
纳武利尤单抗与伊匹木单抗联合用药或单药治疗初治黑色素瘤
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Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia.低剂量地西他滨联合或不联合丙戊酸治疗骨髓增生异常综合征和急性髓系白血病的 2 期随机研究结果。
Cancer. 2015 Feb 15;121(4):556-61. doi: 10.1002/cncr.29085. Epub 2014 Oct 21.
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Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.通过抑制髓系来源细胞消除对免疫检查点阻断有抗性的转移性小鼠肿瘤。
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.抗 PD-1 抗体在癌症中的安全性、活性和免疫相关性。
N Engl J Med. 2012 Jun 28;366(26):2443-54. doi: 10.1056/NEJMoa1200690. Epub 2012 Jun 2.