Suppressive activity of human regulatory T cells is maintained in the presence of TNF.
作者信息
Zaragoza Bruno, Chen Xin, Oppenheim Joost J, Baeyens Audrey, Gregoire Sylvie, Chader Driss, Gorochov Guy, Miyara Makoto, Salomon Benoît L
机构信息
Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), 91 Bd de l'hôpital, Paris, France.
Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
出版信息
Nat Med. 2016 Jan;22(1):16-7. doi: 10.1038/nm.4019.
Abstract
摘要
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Suppressive activity of human regulatory T cells is maintained in the presence of TNF.在肿瘤坏死因子存在的情况下，人类调节性T细胞的抑制活性得以维持。
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Reply to Suppressive activity of human regulatory T cells is maintained in the presence of TNF.在肿瘤坏死因子存在的情况下，人调节性T细胞的应答抑制活性得以维持。
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本文引用的文献
1
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis.FOXP3 的磷酸化控制调节性 T 细胞的功能，并在类风湿关节炎中受到 TNF-α 的抑制。
Nat Med. 2013 Mar;19(3):322-8. doi: 10.1038/nm.3085. Epub 2013 Feb 10.
2
Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs.致病性 T 细胞通过增强 Tregs 对小鼠自身免疫性糖尿病具有矛盾的保护作用。
J Clin Invest. 2010 Dec;120(12):4558-68. doi: 10.1172/JCI42945. Epub 2010 Nov 22.
3
Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.共刺激分子 TNFR2 的表达诱导 CD4+FoxP3-常规 T 细胞抵抗 CD4+FoxP3+调节性 T 细胞的抑制作用。
J Immunol. 2010 Jul 1;185(1):174-82. doi: 10.4049/jimmunol.0903548. Epub 2010 Jun 4.
4
Protein kinase C-theta mediates negative feedback on regulatory T cell function.蛋白激酶 C-θ负反馈调节调节性 T 细胞功能。
Science. 2010 Apr 16;328(5976):372-6. doi: 10.1126/science.1186068. Epub 2010 Mar 25.
5
TNF activates a NF-kappaB-regulated cellular program in human CD45RA- regulatory T cells that modulates their suppressive function.TNF 激活人 CD45RA-调节性 T 细胞中 NF-κB 调节的细胞程序，调节其抑制功能。
J Immunol. 2010 Apr 1;184(7):3570-81. doi: 10.4049/jimmunol.0902070. Epub 2010 Feb 24.
6
Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.TNFR2 和 CD25 的共表达在人外周血中鉴定出更多的功能性 CD4+FOXP3+调节性 T 细胞。
Eur J Immunol. 2010 Apr;40(4):1099-106. doi: 10.1002/eji.200940022.
7
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.前沿：TNFR2的表达定义了小鼠CD4+CD25+FoxP3+调节性T细胞的最大抑制性子集：对肿瘤浸润调节性T细胞的适用性
J Immunol. 2008 May 15;180(10):6467-71. doi: 10.4049/jimmunol.180.10.6467.
8
Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.肿瘤坏死因子（TNF）与2型肿瘤坏死因子受体（TNF receptor type 2）的相互作用可促进小鼠CD4+CD25+调节性T细胞的扩增及功能。
J Immunol. 2007 Jul 1;179(1):154-61. doi: 10.4049/jimmunol.179.1.154.
9
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.抗TNF-α疗法通过转化生长因子-β在类风湿关节炎患者中诱导出独特的调节性T细胞群体。
J Exp Med. 2007 Jan 22;204(1):33-9. doi: 10.1084/jem.20061531. Epub 2007 Jan 2.
10
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.肿瘤坏死因子下调人类CD4+CD25高表达调节性T细胞的功能。
Blood. 2006 Jul 1;108(1):253-61. doi: 10.1182/blood-2005-11-4567. Epub 2006 Mar 14.
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