Kuchta T, Straková H, Sidóová E
Cesk Farm. 1989 Apr;38(3):139-40.
The inhibitory effectiveness of 2-alkylthio-6-amino- and 2-alkylthio-6-formamidobenzothiazoles (19 derivatives altogether) on the transformation of the yeast-like form of Candida albicans into the mycelial form (1 strain from the collection and 2 clinical isolates) was investigated. Most derivatives tested, similarly as the standard 2-mercaptobenzothiazole (Dermacid), did not exert any difference between the inhibitory effectiveness on filamentation and the inhibition of the growth and reproduction of the yeast-like form. However, the best derivative, 6-amino-2-n-pentylthiobenzothiazole, showed as much as 25-fold higher inhibitory effectiveness on the transformation of the yeast-like form into the mycelial one than MIC.
研究了2-烷硫基-6-氨基苯并噻唑和2-烷硫基-6-甲酰氨基苯并噻唑（共19种衍生物）对白色念珠菌酵母样形态向菌丝体形态转化的抑制效果（1株标准菌株和2株临床分离株）。与标准品2-巯基苯并噻唑（德美净）类似，大多数测试衍生物对丝状化的抑制效果与对酵母样形态生长和繁殖的抑制之间没有差异。然而，最佳衍生物6-氨基-2-正戊硫基苯并噻唑对酵母样形态向菌丝体形态转化的抑制效果比最低抑菌浓度（MIC）高25倍。
