Abid Abubakar, Mieloszyk Rebecca J, Verghese George C, Krauss Baruch S, Heldt Thomas
Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug;2015:1687-90. doi: 10.1109/EMBC.2015.7318701.
We propose a highly-simplified single-alveolus mechanistic model of lung mechanics and gas mixing that leads to an analytical solution for carbon dioxide partial pressure in exhaled breath, as measured by time-based capnography. Using this solution, we estimate physiological parameters of the lungs on a continuous, breath-by-breath basis. We validate our model with capnograms from 15 subjects responding positively (>20% FEV1 drop from baseline) to methacholine challenge, and subsequently recovering with bronchodilator treatment. Our results suggest that parameter estimates from capnography may provide discriminatory value for lung function comparable to spirometry, thus warranting more detailed study.
我们提出了一种高度简化的肺力学和气体混合单肺泡力学模型，该模型可得出通过基于时间的二氧化碳描记法测量的呼出气中二氧化碳分压的解析解。利用该解，我们能够逐次呼吸地连续估计肺部的生理参数。我们用15名对乙酰甲胆碱激发试验呈阳性反应（FEV1较基线下降>20%）且随后通过支气管扩张剂治疗恢复的受试者的二氧化碳描记图对我们的模型进行了验证。我们的结果表明，来自二氧化碳描记法的参数估计可能为肺功能提供与肺活量测定法相当的鉴别价值，因此值得进行更详细的研究。
