Bingham P R, Riddle M C
Diabetes Educ. 1989 Sep-Oct;15(5):450-5. doi: 10.1177/014572178901500516.
The literature on type II (noninsulin-dependent diabetes mellitus) proposes many forms of treatment. This diversity suggests that there is no single best way to treat this condition. At Oregon Health Sciences University, we have been using the combination of insulin given in the evening and sulfonylurea drugs given during the day as an alternative to multiple-dose insulin regimens when diet or diet and oral hypoglycemic agent therapies do not achieve adequate glucose control. This approach, while effective in our experience, is not widely accepted. This paper reviews the literature on combined insulin and sulfonylurea therapy for treatment of certain stages of type II diabetes, the rationale for use of this therapy, and our experience to date.
关于II型（非胰岛素依赖型糖尿病）的文献提出了多种治疗方式。这种多样性表明，治疗这种疾病没有单一的最佳方法。在俄勒冈健康与科学大学，当饮食或饮食与口服降糖药治疗无法实现充分的血糖控制时，我们一直将晚间注射胰岛素与白天服用磺脲类药物相结合，作为多剂量胰岛素治疗方案的替代方法。根据我们的经验，这种方法虽然有效，但并未被广泛接受。本文回顾了关于胰岛素与磺脲类药物联合治疗II型糖尿病某些阶段的文献、使用这种治疗方法的基本原理以及我们目前的经验。
