激光多普勒信号的小波分析以评估皮肤灌注。

Wavelet analysis of the Laser Doppler signal to assess skin perfusion.

作者信息

Bagno Andrea, Martini Romeo

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:7374-7. doi: 10.1109/EMBC.2015.7320095.

DOI:10.1109/EMBC.2015.7320095

Abstract

The hemodynamics of skin microcirculation can be clinically assessed by means of Laser Doppler Fluxmetry. Laser Doppler signals show periodic oscillations because of fluctuations of microvascular perfusion (flowmotion), which are sustained by contractions and relaxations of arteriolar walls rhythmically changing vessels diameter (vasomotion). The wavelet analysis applied to Laser Doppler signals displays six characteristic frequency intervals, from 0.005 to 2 Hz. Each interval is assigned to a specific structure of the cardiovascular system: heart, respiration, vascular myocites, sympathetic terminations, and endothelial cells (dependent and independent on nitric oxide). Therefore, mechanisms of skin perfusion can be investigated through wavelet analysis. In the present work, examples of methods and results of wavelet analysis applied to Laser Doppler signals are reported. Laser Doppler signals were acquired in two groups of patients to check possible changes in vascular activities, before and after occlusive reactive hyperaemia, and before and after revascularization.

摘要

皮肤微循环的血流动力学可通过激光多普勒血流仪进行临床评估。由于微血管灌注（血流运动）的波动，激光多普勒信号呈现出周期性振荡，而这种波动是由小动脉壁有节奏地改变血管直径（血管运动）的收缩和舒张维持的。应用于激光多普勒信号的小波分析显示出六个特征频率区间，从0.005到2赫兹。每个区间都对应心血管系统的特定结构：心脏、呼吸、血管平滑肌细胞、交感神经末梢以及内皮细胞（依赖和不依赖一氧化氮）。因此，可以通过小波分析研究皮肤灌注机制。在本研究中，报告了应用于激光多普勒信号的小波分析方法及结果的实例。在两组患者中采集激光多普勒信号，以检查在闭塞性反应性充血前后以及血管重建前后血管活动的可能变化。