Clark John W
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:7796-9. doi: 10.1109/EMBC.2015.7320200.
We here review existing models of vascular smooth muscle cell, endothelial cell and cell-cell communication, which have been developed to better understand vascular tone and blood flow autoregulation. In particular, we discuss models that intended to explain modulation of myogenic tone by intraluminal pressure in resistance arterioles. Modeling efforts in the recent past have witnessed a shift from empirical models to models with mechanistic details that underscore different physical aspects of vascular regulation. Future models should synthesize mechanistic interactions in a hierarchy, from molecular regulation of ion channels to whole organ blood flow control.
我们在此回顾现有的血管平滑肌细胞、内皮细胞及细胞间通讯模型，这些模型的建立是为了更好地理解血管张力和血流自动调节。特别地，我们讨论旨在解释阻力小动脉腔内压力对肌源性张力调节作用的模型。过去的建模工作已见证了从经验模型向具有强调血管调节不同物理方面的机制细节模型的转变。未来的模型应在从离子通道的分子调节到全器官血流控制的层次体系中综合机制相互作用。
