禁食对前列腺癌患者（18）F-氟胆碱胃肠道摄取及淋巴结转移检测的影响。

Impact of fasting on (18)F-fluorocholine gastrointestinal uptake and detection of lymph node metastases in patients with prostate cancer.

作者信息

Wondergem Maurits, van der Zant Friso M, Knol Remco J J, Pruim Jan, de Jong Igle J

机构信息

Department of Nuclear Medicine, Medical Center Alkmaar, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands.

Department of Urology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

EJNMMI Res. 2016 Dec;6(1):2. doi: 10.1186/s13550-015-0159-2. Epub 2016 Jan 6.

DOI:10.1186/s13550-015-0159-2

PMID:26739297

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4703602/

Abstract

BACKGROUND

(18)F-fluorocholine PET/CT is used to detect lymph node metastases in prostate cancer patients. Physiological (18)F-fluorocholine in the gastrointestinal tract, especially in the intestines, may interfere with the detection of malignant lymph nodes. Fasting is frequently proposed in literature; however, scientific support is lacking. This study aims to determine the impact of fasting on (18)F-fluorocholine uptake in the gastrointestinal tract.

METHODS

Eighty patients were studied, 40 fasted for at least 6 h prior to (18)F-fluorocholine administration while the other 40 did not fast. (18)F-fluorocholine uptake pattern and intensity were evaluated in the intestine near the abdominal aorta and four regions near the iliac arteries. (18)F-fluorocholine intensity was also measured in the liver, pancreas, stomach and spleen.

FINDINGS

No statistically significant differences were found in (18)F-fluorocholine uptake in the gastrointestinal tract between the fasting and non-fasting group.

CONCLUSIONS

Fasting for 6 h has no effect on (18)F-fluorocholine uptake in the gastrointestinal tract. Therefore, no effects on the detection of malignant lymph nodes are expected, and fasting is not recommended in our opinion.

摘要