Physiologic effects of tissue oxygenation on wound healing.

Researchers have documented the importance of oxygen as a substrate during tissue healing. Development of knowledge in this area is primarily based on studies conducted in animals with limited studies of tissue oxygen tensions in human beings. However, investigators have consistently shown that a sufficient oxygen supply to tissue is critical to the healing process and the avoidance of wound infection. Research in the area of tissue oxygenation and wound healing is reviewed and implications for nursing practice and research are proposed. Studies that will address the effect of clinical interventions on physiologic processes, such as oxygen delivery to healing tissues, are needed to expand the scientific foundation for nursing practice.