Hemsworth Jaimie, Kumwenda Chiza, Arimond Mary, Maleta Kenneth, Phuka John, Rehman Andrea M, Vosti Stephen A, Ashorn Ulla, Filteau Suzanne, Dewey Kathryn G, Ashorn Per, Ferguson Elaine L
Department of Population Health, Nutrition Group,
Department for International Health, School of Medicine, and.
J Nutr. 2016 Feb;146(2):326-34. doi: 10.3945/jn.115.215327. Epub 2016 Jan 6.
Low intakes of good-quality complementary foods (CFs) contribute to undernutrition and consequently negatively affect health, growth, and development. Lipid-based nutrient supplements (LNSs) are designed to ensure dietary adequacy in micronutrients and essential fatty acids and to provide some energy and high-quality protein. In populations in which acute energy deficiency is rare, the dose-dependent effect of LNSs on CF intakes is unknown.
The objective of this study was to evaluate the difference in energy and macronutrient intakes from CF between a control (no supplement) group and 3 groups that received 10, 20, or 40 g LNS/d.
We collected repeated interactive 24-h dietary recalls from caregivers of rural Malawian 9- to 10-mo-old infants (n = 748) to estimate dietary intakes (LNS and all non-breast-milk foods) of energy and macronutrients and their dietary patterns. All infants were participating in a 12-mo randomized controlled trial to investigate the efficacy of various doses of LNS for preventing undernutrition.
Dietary energy intakes were significantly higher among infants in the LNS intervention groups than in the control group (396, 406, and 388 kcal/d in the 10-, 20-, and 40-g LNS/d groups, respectively, compared with 345 kcal/d; each pairwise P < 0.05), but no significant differences were found in energy intakes between groups who were administered the different LNS doses (10 g LNS/d compared with 20 g LNS/d: P = 0.72; 10 g LNS/d compared with 40 g LNS/d: P ≥ 0.67; 20 g LNS/d compared with 40 g LNS/d: P = 0.94). Intakes of protein and fat were significantly higher in the LNS intervention groups than in the control group. No significant intergroup differences were found in median intakes of energy from non-LNS CFs (357, 347, and 296 kcal/d in the 10-, 20-, and 40-g LNS/d groups, respectively, compared with 345 kcal/d in the control group; P = 0.11).
LNSs in doses of 10-40 g/d increase intakes of energy and macronutrients among 9- to 10-mo-old Malawian infants, without displacing locally available CFs. This trial was registered at clinicaltrials.gov as NCT00945698.
优质辅食摄入量低会导致营养不良，进而对健康、生长和发育产生负面影响。基于脂质的营养补充剂（LNS）旨在确保微量营养素和必需脂肪酸的膳食充足，并提供一些能量和优质蛋白质。在急性能量缺乏罕见的人群中，LNS对辅食摄入量的剂量依赖性影响尚不清楚。
本研究的目的是评估对照组（不补充）与接受10、20或40 g/d LNS的三组之间辅食能量和宏量营养素摄入量的差异。
我们收集了马拉维农村9至10个月大婴儿（n = 748）的照顾者重复的24小时交互式饮食回忆，以估计能量和宏量营养素的膳食摄入量（LNS和所有非母乳食品）及其饮食模式。所有婴儿都参与了一项为期12个月的随机对照试验，以研究不同剂量LNS预防营养不良的效果。
LNS干预组婴儿的膳食能量摄入量显著高于对照组（10 g/d、20 g/d和40 g/d LNS组分别为396、406和388 kcal/d，而对照组为345 kcal/d；每组两两比较P < 0.05），但不同LNS剂量组之间的能量摄入量没有显著差异（10 g/d LNS与20 g/d LNS比较：P = 0.72；10 g/d LNS与40 g/d LNS比较：P≥0.67；20 g/d LNS与40 g/d LNS比较：P = 0.94）。LNS干预组的蛋白质和脂肪摄入量显著高于对照组。非LNS辅食的能量中位数摄入量在组间没有显著差异（10 g/d、20 g/d和40 g/d LNS组分别为357、347和296 kcal/d，而对照组为345 kcal/d；P = 0.11）。
10 - 40 g/d剂量的LNS可增加9至10个月大马拉维婴儿的能量和宏量营养素摄入量，且不会取代当地可得的辅食。该试验已在clinicaltrials.gov注册，注册号为NCT00945698。
