Suppr超能文献

德国初级医疗实践中痴呆症诊断的风险因素。

Risk factors for dementia diagnosis in German primary care practices.

作者信息

Booker Anke, Jacob Louis Ec, Rapp Michael, Bohlken Jens, Kostev Karel

机构信息

IMS HEALTH,Frankfurt,Germany.

Department of biology,École Normale Supérieure de Lyon,Lyon,France.

出版信息

Int Psychogeriatr. 2016 Jul;28(7):1059-65. doi: 10.1017/S1041610215002082. Epub 2016 Jan 8.

Abstract

BACKGROUND

Dementia is a psychiatric condition the development of which is associated with numerous aspects of life. Our aim was to estimate dementia risk factors in German primary care patients.

METHODS

The case-control study included primary care patients (70-90 years) with first diagnosis of dementia (all-cause) during the index period (01/2010-12/2014) (Disease Analyzer, Germany), and controls without dementia matched (1:1) to cases on the basis of age, sex, type of health insurance, and physician. Practice visit records were used to verify that there had been 10 years of continuous follow-up prior to the index date. Multivariate logistic regression models were fitted with dementia as a dependent variable and the potential predictors.

RESULTS

The mean age for the 11,956 cases and the 11,956 controls was 80.4 (SD: 5.3) years. 39.0% of them were male and 1.9% had private health insurance. In the multivariate regression model, the following variables were linked to a significant extent with an increased risk of dementia: diabetes (OR: 1.17; 95% CI: 1.10-1.24), lipid metabolism (1.07; 1.00-1.14), stroke incl. TIA (1.68; 1.57-1.80), Parkinson's disease (PD) (1.89; 1.64-2.19), intracranial injury (1.30; 1.00-1.70), coronary heart disease (1.06; 1.00-1.13), mild cognitive impairment (MCI) (2.12; 1.82-2.48), mental and behavioral disorders due to alcohol use (1.96; 1.50-2.57). The use of statins (OR: 0.94; 0.90-0.99), proton-pump inhibitors (PPI) (0.93; 0.90-0.97), and antihypertensive drugs (0.96, 0.94-0.99) were associated with a decreased risk of developing dementia.

CONCLUSIONS

Risk factors for dementia found in this study are consistent with the literature. Nevertheless, the associations between statin, PPI and antihypertensive drug use, and decreased risk of dementia need further investigations.

摘要

背景

痴呆是一种与生活诸多方面相关的精神疾病。我们的目的是评估德国初级保健患者的痴呆风险因素。

方法

这项病例对照研究纳入了在索引期(2010年1月 - 2014年12月)首次诊断为痴呆(全因性)的初级保健患者(70 - 90岁)(德国疾病分析器),以及在年龄、性别、医疗保险类型和医生方面与病例(1:1)匹配的无痴呆对照。通过实践就诊记录核实索引日期前有10年的连续随访。多变量逻辑回归模型以痴呆为因变量并纳入潜在预测因素。

结果

11,956例病例和11,956例对照的平均年龄为80.4岁(标准差:5.3)。其中39.0%为男性,1.9%拥有私人医疗保险。在多变量回归模型中,以下变量与痴呆风险增加在很大程度上相关:糖尿病(比值比:1.17;95%置信区间:1.10 - 1.24)、脂质代谢(1.07;1.00 - 1.14)、中风包括短暂性脑缺血发作(1.68;1.57 - 1.80)、帕金森病(PD)(1.89;1.64 - 2.19)、颅内损伤(1.30;1.00 - 1.70)、冠心病(1.06;1.00 - 1.13)、轻度认知障碍(MCI)(2.12;1.82 - 2.48)、酒精所致精神和行为障碍(1.96;1.50 - 2.57)。使用他汀类药物(比值比:0.94;0.90 - 0.99)、质子泵抑制剂(PPI)(0.93;0.90 - 0.97)和抗高血压药物(0.96,0.94 - 0.99)与痴呆发生风险降低相关。

结论

本研究中发现的痴呆风险因素与文献一致。然而,他汀类药物、PPI和抗高血压药物的使用与痴呆风险降低之间的关联需要进一步研究。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验