Knop J, Delling G, Salzer-Kuntschik M, Berberich R, Feine U, Feistel H, Ladenstein R, Müller-Schauenburg W, Schober O, Szabo Z
Nuklearmedizinische Einrichtungen der Universitäten Hamburg.
Klin Padiatr. 1989 Jul-Aug;201(4):285-92. doi: 10.1055/s-2008-1026716.
The prediction of histologic tumor response to preoperative chemotherapy was assessed by quantitative scintigraphic follow-up examinations of 54 osteosarcomas. Tumor/non-tumor scintimetry using 99mTc labeled diphosphonates allowed accurate prediction of tumor response in 28 of 30 tumors (accuracy = 93%) after completion and in 10 of 12 osteosarcomas (accuracy = 83%) at the half-way stage of preoperative chemotherapy evaluating only those tumors which showed convergent changes of tumor/non-tumor ratios in the perfusion and the mineral phase. At the half-way stage, however, evaluation of chemotherapy effects was complicated in 12 of 23 osteosarcomas by diverging T/NT ratios. In contrast, quantification and mapping of the tumor plasma volume and 99mTc MDP plasma clearance predicted the histologic tumor response to chemotherapy in 12 of 13 tumors (accuracy = 92%) after completion and in all 11 cases (accuracy = 100%) at the half-way stage.
通过对54例骨肉瘤进行定量闪烁扫描随访检查，评估了组织学肿瘤对术前化疗反应的预测情况。使用99mTc标记的二膦酸盐进行肿瘤/非肿瘤闪烁扫描，在术前化疗完成后，30例肿瘤中有28例（准确率 = 93%）以及在术前化疗中途阶段，仅评估灌注和矿化期肿瘤/非肿瘤比值呈现趋同变化的12例骨肉瘤中的10例（准确率 = 83%）能够准确预测肿瘤反应。然而，在中途阶段，23例骨肉瘤中有12例因肿瘤/非肿瘤比值发散而使化疗效果评估变得复杂。相比之下，肿瘤血容量和99mTc MDP血浆清除率的定量及图谱分析在术前化疗完成后，13例肿瘤中的12例（准确率 = 92%）以及在中途阶段的所有11例病例（准确率 = 100%）中能够预测组织学肿瘤对化疗的反应。
