Li Ying, Li Daqing, Raisman Geoffrey
Spinal Repair Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Brain Res. 2016 Aug 15;1645:18-21. doi: 10.1016/j.brainres.2015.12.038. Epub 2015 Dec 31.
In 1969 a paper entitled Neuronal plasticity in the septal nuclei of the adult rat proposed that new synapses are formed in the adult brain after injury (Raisman, 1969). The quantitative electron microscopic study of the timed responses to selective partial denervation of the neuropil of the adult rat septal nuclei after distant transection of the hippocampal efferent axons in the fimbria showed that the new synapses arise by sprouting of surviving adjacent synapses which selectively take over the previously denervated sites and thus restore the number of synapses to normal. This article presents the evidence for the role of perisynaptic astrocytic processes in the removal and formation of synapses and considers its significance as one of the three major divisions of the astrocytic surface in terms of the axonal responses to injury and regeneration. This article is part of a Special Issue entitled SI:50th Anniversary Issue.
1969年，一篇题为《成年大鼠隔核中的神经元可塑性》的论文提出，成年大脑在受伤后会形成新的突触（雷斯曼，1969年）。对成年大鼠海马传出轴突在穹窿处进行远距离横断后，对成年大鼠隔核神经毡选择性部分去神经支配的定时反应进行的定量电子显微镜研究表明，新突触是由存活的相邻突触发芽形成的，这些突触选择性地接管先前去神经支配的部位，从而使突触数量恢复正常。本文提供了突触周围星形胶质细胞过程在突触消除和形成中的作用的证据，并从轴突对损伤和再生的反应角度，将其作为星形胶质细胞表面三个主要部分之一的意义进行了探讨。本文是名为《特刊：50周年纪念刊》的特刊的一部分。
