Department of Molecular Oral Medicine and Maxillofacial Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Japan.
Clinic of Oral and Maxillofacial Surgery, Hiroshima University Hospital, Japan.
Photodiagnosis Photodyn Ther. 2016 Jun;14:104-10. doi: 10.1016/j.pdpdt.2015.12.009. Epub 2015 Dec 30.
Photodynamic therapy (PDT) is a very effective treatment for superficial malignancies that does not result in loss of normal tissue. Here, we report successful PDT treatment of superficial oral cancers and its clinical outcome with long-term follow up.
Thirty-four superficial oral squamous cell carcinomas were treated with PDT, and the effects were evaluated. Each patient received Photofrin (2mg/kg) intravenously 48h prior to light irradiation. Photoradiation was performed at doses of 100-150J/cm(2) using a 630-nm wavelength excimer dye laser.
Six months after PDT, 30 patients (88.2%) showed complete responses while 9 patients (26.5%) had local relapses during long-term follow-up. The 5-year overall survival, disease-specific survival, and disease-free survival rates were 76.5%, 84.6%, and 63.3%, respectively. Lesions with red patches had a significantly higher recurrence rate than lesions with white patches. Accurate evaluation of the extent of lesions and appropriate photoradiation were important in improving outcomes. Adverse events observed included sunburn and sequestrum formation of alveolar bone. No abnormal laboratory values or systemic complications were observed.
PDT using Photofrin as the photosensitizer is an effective treatment modality for superficial oral carcinomas, with excellent healing and minimal side effects.
光动力疗法（PDT）是一种非常有效的治疗浅表恶性肿瘤的方法，不会导致正常组织丧失。在此，我们报告了 PDT 治疗浅表口腔癌的成功案例，并对其长期随访的临床结果进行了评估。
34 例浅表口腔鳞状细胞癌患者接受 PDT 治疗，并对疗效进行了评估。每位患者在光照射前 48 小时静脉注射 Photofrin（2mg/kg）。光辐射采用 630nm 波长的激光染料，剂量为 100-150J/cm²。
PDT 治疗后 6 个月，30 例患者（88.2%）完全缓解，9 例患者（26.5%）在长期随访期间出现局部复发。5 年总生存率、疾病特异性生存率和无病生存率分别为 76.5%、84.6%和 63.3%。有红斑的病变比有白班的病变复发率显著更高。准确评估病变范围和适当的光辐射对于改善疗效非常重要。观察到的不良反应包括晒伤和牙槽骨的骨隔离形成。未观察到异常的实验室值或全身并发症。
以 Photofrin 为光敏剂的 PDT 是治疗浅表口腔癌的有效方法，具有良好的愈合效果和最小的副作用。
