抗癌团队合作：交叉呈递树突状细胞与治疗性单克隆抗体协同作用。

Anticancer Teamwork: Cross-Presenting Dendritic Cells Collaborate with Therapeutic Monoclonal Antibodies.

机构信息

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Canada.

Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Canada. Department of Oncology and Ludwig Center for Cancer Research, University of Lausanne, Switzerland.

出版信息

Cancer Discov. 2016 Jan;6(1):17-9. doi: 10.1158/2159-8290.CD-15-1366.

DOI:10.1158/2159-8290.CD-15-1366

PMID:26747893

Abstract

Cross-presentation of tumor antigens represents a key pathway in antitumor immune responses that can be exploited to synergize not only with the already prominent "checkpoint blockade," but also with newer attempts to use T-cell stimulatory monoclonal antibodies in immunotherapy.

摘要

肿瘤抗原交叉呈递代表了抗肿瘤免疫反应的一个关键途径，不仅可以与已经突出的“检查点阻断”协同作用，还可以与使用 T 细胞刺激单克隆抗体进行免疫治疗的新尝试协同作用。