Soussy C J, Thabaut A, Bismuth R, Morel C, Berthelot G, Chanal M, Derlot E
Service de Bactériologie, Centre Hospitalier Universitaire Henri-Mondor, Creteil.
Pathol Biol (Paris). 1989 May;37(5):358-63.
Minimal inhibitory concentration (MIC) of miokamycin (M) were evaluated by agar dilution for 1,024 bacterial strains isolated in 6 hospitals and classed as a function of susceptibility and resistance to macrolides, lincosamides, streptogramins group (MLS). MIC of M ranged from 0.25 to 4 micrograms/ml (mode MIC 1-2) on Staphylococcus susceptible to MLS and on MLSB inducible strains; M was inactive on MLSB constitutive strains. MIC of M ranged from 0.016 to 4 micrograms/ml (mode MIC 0.12 to 0.5) for Streptococci and Pneumococci susceptible to erythromycin (E) and from 0.12 to greater than 128 for strains resistant to E. Enterococci susceptible to E were inhibited by 0.5 to 2 micrograms/ml (mode MIC 1) and strains resistant to E by 4 to greater than 128. Haemophilus were inhibited by 2 to 64 micrograms/ml (mode MIC 32), Neisseria by 0.12 to 4 (mode MIC 0.5-1) and B. catarrhalis by 0.12 to 8 (mode MIC 1). L. pneumophila was very susceptible to M: MIC 0.016 to 0.12 (mode MIC 0.06). MIC of M ranged generally from 0.5 to 2 micrograms/ml (mode MIC 1) for C. perfringens and from 0.03 to 2 (mode MIC 1) for B. fragilis. Thus, M was shown to be among macrolide antibiotics of resistance non-inducing type on MLSB inducible resistance strains. Its activity was similar to that of spiramycin slightly superior on Staphylococci, slightly inferior on Streptococci and Enterococci, similar on Pneumococci, very superior on Neisseria, Legionella and anaerobes. M had a good activity on Branhamella and, as others macrolides, was poorly active on Haemophilus.
采用琼脂稀释法对6家医院分离的1024株细菌进行了米卡霉素（M）的最低抑菌浓度（MIC）评估，并根据对大环内酯类、林可酰胺类、链阳菌素类（MLS）的敏感性和耐药性进行分类。对于对MLS敏感的金黄色葡萄球菌和MLSB诱导型菌株，M的MIC范围为0.25至4微克/毫升（MIC模式为1 - 2）；M对MLSB组成型菌株无活性。对于对红霉素（E）敏感的链球菌和肺炎球菌，M的MIC范围为0.016至4微克/毫升（MIC模式为0.12至0.5），而对E耐药的菌株MIC范围为0.12至大于128。对E敏感的肠球菌被0.5至2微克/毫升（MIC模式为1）抑制，对E耐药的菌株被4至大于128抑制。嗜血杆菌被2至64微克/毫升（MIC模式为32）抑制，奈瑟菌被0.12至4（MIC模式为0.5 - 1）抑制，卡他莫拉菌被0.12至8（MIC模式为1）抑制。嗜肺军团菌对M非常敏感：MIC为0.016至0.12（MIC模式为0.06）。对于产气荚膜梭菌，M的MIC一般范围为0.5至2微克/毫升（MIC模式为1），对于脆弱拟杆菌，MIC范围为0.03至2（MIC模式为1）。因此，在MLSB诱导耐药菌株中，M被证明是不诱导耐药型的大环内酯类抗生素之一。其活性与螺旋霉素相似，在金黄色葡萄球菌上略强，在链球菌和肠球菌上略弱，在肺炎球菌上相似，在奈瑟菌、军团菌和厌氧菌上非常强。M对布兰汉菌有良好活性，并且与其他大环内酯类一样，对嗜血杆菌活性较差。
